This Month in JNM

¹⁸F-DOPA PET applications: Nanni and colleagues provide an overview of the use of ¹⁸F-DOPA in PET and PET/CT imaging for neurologic and oncologic indications and preview a related article in this issue of JNM.
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Qualitative and quantitative PET in lymphoma: Weber looks at the success of ¹⁸F-FDG PET in assessment of tumor response to chemotherapy for Hodgkin's and non-Hodgkin's lymphoma and considers the advantages of adding quantitative parameters to visual assessment.
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Limitations of CT in PET/CT: Gollub and colleagues explore the technical causes and diagnostic significance of missed findings in the unenhanced CT portion of PET/CT scans.
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PET response evaluation for NSCLC: de Geus-Oei and colleagues assess the value of ¹⁸F-FDG PET in predicting chemotherapy response in patients with non–small cell lung cancer and compare 2 methods for quantifying changes in glucose metabolism in such studies.
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Carbidopa ¹⁸F-DOPA PET in paraganglioma: Timmers and colleagues investigate the sensitivity of ¹⁸F-DOPA PET in the detection of paraganglioma and its metastatic lesions and evaluate whether tracer uptake by tumors is enhanced by carbidopa.
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Interval sentinel lymph nodes and melanoma: Matter and colleagues review the incidence, lymphatic anatomy, and metastatic risk of interval sentinel nodes, as well as the role of preoperative lymphoscintigraphy in reviewing all known lymphatic areas.
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PET staging of nasopharyngeal cancer: Liu and colleagues provide evidence that ¹⁸F-FDG PET can replace multimodality conventional work-ups in primary staging of patients with nonkeratinizing nasopharyngeal carcinoma.
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Dental effects of radioiodine therapy: Walter and colleagues investigate the long-term incidence of dental problems after high-dose ¹³¹I therapy for differentiated thyroid cancer and describe associated risk factors.
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Early SUV assessment in lymphoma: Lin and colleagues assess the prognostic value of standardized uptake values in early ¹⁸F-FDG PET imaging in patients with diffuse large B-cell lymphoma and compare their results with those from routine visual analysis.
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Nicotinic receptor availability in nonsmokers: Cosgrove and colleagues use SPECT and MRI to examine the availability of nicotinic acetylcholine receptors in healthy men and women and assess whether menstrual phase in women affects these findings.
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Perspectives on dementia: Inui and colleagues assess a combined SPECT approach using ¹²³I-IMP for brain perfusion imaging, ¹²³I-MIBG for cardiac sympathetic nerve function, and ^99mTc-sestamibi for myocardial function in patients with probable or possible dementia with Lewy bodies.
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¹⁸F-FDOPA kinetics in brain tumors: Schiepers and colleagues investigate the action of this amino acid analog using PET in patients with brain tumors to derive a useful clinical model of uptake for different types of neoplasms.
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Variable cardiac uptake in oncology PET: Inglese and colleagues analyze global and regional ¹⁸F-FDG cardiac images in fasted cancer patients free from cardiac disease and offer a word of caution on the diagnosis of myocardial scar in such patients.
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Early tetrofosmin imaging: Rossi and colleagues, representing the multicenter Myoview Imaging Optimization study, assess whether early myocardial tetrofosmin SPECT imaging is feasible and as accurate as standard delayed imaging in detecting coronary artery disease in patients with anginal symptoms.
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Nicorandil therapy in acute MI: Kasama and colleagues use ¹²³I-MIBG scintigraphy to explore the long-term effects of this adenosine triphosphate–sensitive potassium channel opener in patients with acute myocardial infarction.
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Bystander and low–dose rate effects: Sgouros and colleagues provide an educational overview of the history, key experiments, and current understanding of these radiation-induced effects and pose questions about their relevance in radionuclide therapy.
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Weak sources in PET: Goertzen and colleagues evaluate the potential effects of intrinsic radioactivity in lutetium oxyorthosilicate–based small-animal PET imaging and offer advice on strategies for visualizing weak sources in these scanners.
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PET in breast cell proliferation: Tian and colleagues report on PET imaging and quantitation with a dual-specificity probe that molecularly targets both CCND1 mRNA and insulinlike growth factor 1 receptor in early breast cancer.
Page 1699

Dynamic tracking of cell therapy: Doyle and colleagues study the feasibility of dynamic 3D-PET/CT tracking of ¹⁸F-FDG–labeled circulating progenitor cell therapy during intracoronary injection in a swine model of acute myocardial infarction.
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Uptake of tracers into brown fat: Baba and colleagues determine whether multiple clinically useful radiotracers accumulate in brown adipose tissue and assess the uptake of these tracers in rats kept in normal and cold environments.
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PET and methamphetamine effects: Fowler and colleagues measure the pharmacokinetics of two ¹¹C-labeled methamphetamine enantiomers in the baboon brain and peripheral organs to assess the saturability and pharmacologic specificity of binding.
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HED retention in noncardiac tissues: Thackeray and colleagues explore the retention of ¹¹C-meta-hydroxyephedrine in brown adipose tissue, lung, pancreas, skeletal muscle, and kidney and discuss the potential for novel PET studies of sympathetic nervous system integrity in these tissues.
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⁶⁸Ge/Ga generator postprocessing: Zhernosekov and colleagues describe an efficient method for processing generator-derived ⁶⁸Ga eluates, including the labeling and purification of biomolecules, for radiopharmaceuticals for routine applications.
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ON THE COVER

Mean parametric images illustrating ¹²³I-5-IA-85380 activity in 10 men and 19 women in V_T′ (regional activity divided by total plasma parent between 6 and 8 h) and V_T (regional activity divided by free plasma parent between 6 and 8 h). Across brain regions, the main V_T′ component was significantly greater in women than in men, but the main V_T component did not significantly differ between the sexes.

See page 1637.