Abstract
1777
Objectives: FDG-PET can be limited in diagnosing primary urinary tract malignancies due to normally high urine activity. There is limited number of studies in the literature assessing the value of FDG-PET in urinary tract malignancies. The objective of this study is to evaluate the clinical value of FDG-PET in the detection of metastatic urinary tract malignancies (specifically clear cell type renal and transitional cell carcinomas) as complimentary to the conventional imaging modalities.
Methods: This retrospective study included 31 patients (22 male, 9 female, mean age: 60±15 years). The patients underwent a total number of 37 FDG-PET scans. The final diagnosis was obtained by clinical follow up, which included subsequent conventional imaging modalities (CT, MRI, and bone scan) and/or pathology results. The histopathological types of the tumors included specifically renal carcinomas of clear cell type and transitional cell carcinomas.
Results: The sensitivity, specificity, and accuracy of FDG-PET in the detection of metastatic renal cell carcinomas of clear cell type were 80% (8/10), 100% (3/3), and 85% (11/13) respectively. Whereas the sensitivity, specificity, and accuracy of FDG-PET in the detection of metastatic transitional cell carcinomas were 79% (11/14), 80% (8/10), and 79% (19/24) respectively. The positive predictive value and the negative predictive value of FDG-PET in detecting metastatic renal carcinomas of clear cell type were 100% (8/8), and 60% (3/5) respectively. The positive predictive value and the negative predictive value of FDG-PET in detecting metastatic transitional cell carcinomas were 85% (11/13), and 73% (8/11) respectively.
Conclusions: These preliminary results from one institution of a small sample of patients demonstrate a good accuracy of FDG-PET in the detection of metastatic renal cell carcinomas of clear cell type, and transitional cell carcinomas, which account for the majority of urinary tract malignancies. Although the results of FDG-PET are better in renal cell carcinomas of clear cell type, this may be related to the smaller number of patients.
- Society of Nuclear Medicine, Inc.