Abstract
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Objectives: To explore the clinical risk factors of cardiac event occurrence.
Methods: 1371 consecutively registered patients suspected with coronary artery disease (CAD) were studied using rest SPECT myocardial perfusion imaging (MPI), and 1047 cases (76.37%) were followed up successfully. The mean interval of following up was 33.25±14.95(1~56)months, and even longer than 18 months for patients with no cardiac events.
Results: Of 1047 subjects, 746 males, 301 females, average 55.94±12.46 (16~90) years. 330 pts with Hypertension, 324 pts with Hyperlipemia, 172 pts with Diabetes and 294 pts with the family history of CAD. During the follow up period, MPI was normal in 480 pts, abnormal in 567 cases. Cox proportional regression analysis evaluated the extent of MPI defects, diabetes, age>60, and family history of CAD, the history of smoking and drinking, Hypertension and Hyperlipemia as predictors. By Cox proportional regression analysis, the extent of MPI defects (P<0.001), diabetes (P=0.005), age>60(P=0.007) and family history of CAD (P=0.009) were independent predictor for cardiac events occurrence. The history of smoking and drinking, Hypertension and Hyperlipemia were not associated with cardiac events (Table1). The extent of MPI defects was the most important predictor. Of 1047 patients, there are 28 cardiac events in 194 small defects’ group (1 segment), 28 in 164 moderate defects’ group (2 segments) and 62 in 122 extensive defects’ group (≥3 segments). The per year cardiac events rate occurrence is 0.98%, 5.2% and 14.2% respectively (Pearson chi-square 61.066, P<0.001).
Conclusions: The extent of defects of myocardial perfusion, diabetes, age>60 and family history of CAD are the major predictors of future cardiac events, especially the extent of MPI defects.
- Society of Nuclear Medicine, Inc.