CT Attenuation Correction for Myocardial Perfusion Quantification Using a PET/CT Hybrid Scanner

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FIGURE 1.
(A) Time–activity curves of left ventricular blood pool (□) (input function) and left ventricular myocardium (▪). (B) ROIs for left ventricular cavity and myocardial tissue drawn on a short-axis cut of the heart.
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FIGURE 2.
Percentage difference of CT AC at different tube currents vs. standard ⁶⁸Ge AC.
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FIGURE 3.
Repeated MBF measurements using CT AC (10 mA). Coefficients of variance (COV) are given as percentages.
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FIGURE 4.
Bland–Altman plots of MBF (mL/min/g) in group 3. (A) Comparison of reconstruction algorithms: FBP vs. IT. Top graph shows ⁶⁸Ge AC (RC = 0.22 mL/min/g [29%]). Bottom graph shows CT AC (RC = 0.23 mL/min/g [29%]). (B) Comparison of AC sources: ⁶⁸Ge vs. CT. Top graph shows FBP (RC = 0.13 mL/min/g [17%]). Bottom graph shows IT (RC = 0.15 mL/min/g [19%]).

TABLE 1

Global MBF and COV at Rest and During Stress

Region	Patient 1							Patient 2
		Rest			Stress			Rest			Stress			Rest	Stress
		MBF	COV	MBF	COV	MBF	COV	MBF	COV	MBF	COV	MBF	COV
Septal	0.49 ± 0.03	6	0.87 ± 0.10	12	0.55 ± 0.02	4	1.15 ± 0.07	6	0.88 ± 0.01	1	2.21 ± 0.04	2
Anterior	0.28 ± 0.01	3	0.38 ± 0.01	4	0.35 ± 0.02	7	0.77 ± 0.02	3	0.75 ± 0.04	5	1.03 ± 0.07	7
Lateral	0.28 ± 0.02	9	0.44 ± 0.04	9	0.48 ± 0.04	9	0.93 ± 0.03	4	0.75 ± 0.04	6	1.26 ± 0.06	5
Inferior	0.34 ± 0.03	9	0.40 ± 0.03	9	0.51 ± 0.02	4	0.60 ± 0.03	5	0.78 ± 0.02	2	2.18 ± 0.10	5

Regional myocardial blood flow is in mL/min/g (mean ± SD) of repeated measurements using CT AC (10 mA), and respective coefficients of variance (COV) are given as percentages.