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OtherClinical Investigations

Constancy and Variability of Gallbladder Ejection Fraction: Impact on Diagnosis and Therapy

Gerbail T. Krishnamurthy, Shakuntala Krishnamurthy and Paul H. Brown
Journal of Nuclear Medicine November 2004, 45 (11) 1872-1877;
Gerbail T. Krishnamurthy
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Shakuntala Krishnamurthy
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Paul H. Brown
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  • FIGURE 1.
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    FIGURE 1.

    Correlation between EF-1 and EF-2 in control subjects and patients with CAC and CCC (opioid group excluded). Note good correlation between 2 EFs, with r = 0.73 (P < 0.0001). Solid line shows regression; dashed line shows line of identity.

  • FIGURE 2.
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    FIGURE 2.

    Mean ± SD for first (EF-1) and second (EF-2) GBEF in control, CAC, and CCC groups. EF-1 and EF-2 values are not significantly different within groups (P > 0.05) but are significantly low in CAC (P < 0.0001) and CCC (P < 0.0003) when compared with control subjects.

Tables

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    TABLE 1

    Demography, EFs, Time Interval Between EF-1 aand EF-2, Duration of CCK-8 Infusion, and Final Diagnosis in 52 Patients

    Subject no.Age (y)SexWeight (kg)GBSEF-1EF-2Interval (mo)Cause of low EFFinal DxCCK-8 infusion duration
    154F67No550.1CACCAC3 and 3 min
    249F66No550.3CACCAC3 and 3 min
    333FNo32260.8CACCAC3 and 3 min
    445M156No3141CACCAC10 and 10 min
    533F75No4313CACCAC3 and 10 min
    648F68No1174CACCAC3 and 3 min
    743FNo11268CACCAC3 and 3 min
    845FNo768CACCAC3 and 3 min
    931F82No33279CACCAC3 and 3 min
    1063MNo121911CACCAC3 and 3 min
    1138M70No121012CACCAC3 and 3 min
    1258F69No201218CACCAC3 and 10 min
    1333MNo331923CACCAC3 and 3 min
    1477F82No424424CACCAC3 and 10 min
    1547F85No321124CACCAC3 and 3 min
    1656FNo19226CACCAC3 and 3 min
    1754FNo242527CACCAC3 and 3 min
    1849FNo50233CACCAC3 and 3 min
    1951F145No321444CACCAC3 and 10 min
    2049FNo61248CACCAC3 and 3 min
    2136FNo622648CACCAC3 and 3 min
    2262F95No101548CACCAC3 and 3 min
    2384FNo702060CACCAC3 and 3 min
    2474F64No142698CACCAC3 and 3 min
    2534F113No913398CACCAC3 and 3 min
    2643F68No818168CACCAC3 and 10 min
    2759F73No110168CACCAC3 and 10 min
    2878FYes310.1CCCCCC3 and 3 min
    2972M77Yes25123CCCCCC3 and 3 min
    3037M111Yes12511CCCCCC3 and 3 min
    3180FYes132131CCCCCC3 and 3 min
    3279F69Yes619435N/ACCC3 and 3 min
    3369FYes113279CCCCCC3 and 3 min
    3429FNo7741OpioidNormal3 and 3 min
    3562MNo9581OpioidNormal3 and 3 min
    3646FYes37213OpioidNormal3 and 3 min
    3749F71No183638OpioidNormal3 and 3 min
    3884F125Yes43542OpioidNormal3 and 3 min
    3949F64No994144OpioidNormal3 and 10 min
    4038FNo54591N/ANormal3 and 3 min
    4145M148No68885N/ANormal3 and 3 min
    4240F113No94926N/ANormal10 and 10 min
    4350F95No598511N/ANormal3 and 3 min
    4439F82No368412N/ANormal3 and 10 min
    4529FNo463514N/ANormal3 and 3 min
    4663F80No925024N/ANormal3 and 3 min
    4750FNo898325N/ANormal3 and 3 min
    4847M85No859049N/ANormal3 and 10 min
    4981F66No838548N/ANormal3 and 3 min
    5046FNo526766N/ANormal3 and 3 min
    5156M118No7262156N/ANormal3 and 10 min
    5247F72No4081177N/ANormal3 and 10 min
    • GBS = gallstone; Dx = diagnosis; N/A = not applicable.

    • Normal GBEF is ≥35% with 3-min and ≥50% with 10-min infusion of CCK-8.

    • View popup
    TABLE 2

    GB Emptying Results in 4 Groups of Patients

    CategoryNormal (n = 13)CAC (n = 27)CCC (n = 6)Opioid (n = 6)
    Time between first and second study (mo)45.7 ± 57.237.5 ± 46.126.5 ± 29.539.83 ± 54.02
    Study number12121212
    GBEF
        Mean66.973.924.416.920.827.514.856.5
        SD20.517.722.310.920.934.514.631.7
    • View popup
    TABLE 3

    Time Taken to Convert from Normal to Low EF in 5 Patients

    Subject no.EF-1 (%)EF-2 (%)Interval (mo)Duration of CCK-8 infusion
    144244*243 and 10 min*
    185033333 and 3 min
    216226483 and 3 min
    237020603 and 3 min
    259133983 and 3 min
    Mean63.031.252.6
    SD19.08.9828.9
    • ↵* Normal GBEF is ≥35% with 3-min and ≥50% with 10-min infusion of CCK-8.

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Journal of Nuclear Medicine: 45 (11)
Journal of Nuclear Medicine
Vol. 45, Issue 11
November 1, 2004
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Constancy and Variability of Gallbladder Ejection Fraction: Impact on Diagnosis and Therapy
Gerbail T. Krishnamurthy, Shakuntala Krishnamurthy, Paul H. Brown
Journal of Nuclear Medicine Nov 2004, 45 (11) 1872-1877;

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Constancy and Variability of Gallbladder Ejection Fraction: Impact on Diagnosis and Therapy
Gerbail T. Krishnamurthy, Shakuntala Krishnamurthy, Paul H. Brown
Journal of Nuclear Medicine Nov 2004, 45 (11) 1872-1877;
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