Evaluation of a fluorescent and radiolabeled hybrid somatostatin analog in vitro and in mice bearing H69 neuroendocrine xenografts
C Santini, J Kuil, A Bunschoten, S Pool… - Journal of Nuclear …, 2016 - Soc Nuclear Med
In the treatment of neuroendocrine tumors (NETs), complete surgical removal of malignancy
is generally desirable, because it offers curative results. Preoperative guidance with …
is generally desirable, because it offers curative results. Preoperative guidance with …
Tecnetium-99m as alternative to produce somatostatin-labeled derivatives: comparative biodistribution evaluation with 111in-dtpa-octreotide
IB Melo, LT Ueda, EB Araujo, E Muramoto… - Cellular and Molecular …, 2010 - cellmolbiol.org
Synthetic somatostatin (SST) analogues have been used in the preparation of receptor-
specific radiopharmaceuticals for diagnostic and therapy of neuroendocrine tumors. This …
specific radiopharmaceuticals for diagnostic and therapy of neuroendocrine tumors. This …
Imaging expression of the human somatostatin receptor subtype-2 reporter gene with 68Ga-DOTATOC
H Zhang, MA Moroz, I Serganova, T Ku… - Journal of Nuclear …, 2011 - Soc Nuclear Med
The human somatostatin receptor subtype 2 (hSSTr2)–68Ga-DOTATOC reporter system has
several attractive features for potential translation to human studies. These include a low …
several attractive features for potential translation to human studies. These include a low …
Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings
M De Jong, R Valkema, F Jamar, LK Kvols… - Seminars in nuclear …, 2002 - Elsevier
In preclinical studies in rats we evaluated biodistribution and therapeutic effects of different
somatostatin analogs,[111In-DTPA] octreotide,[90Y-DOTA, Tyr3] octreotide and [177Lu …
somatostatin analogs,[111In-DTPA] octreotide,[90Y-DOTA, Tyr3] octreotide and [177Lu …
Comparison of the therapeutic response to treatment with a 177Lu-labeled somatostatin receptor agonist and antagonist in preclinical models
SU Dalm, J Nonnekens, GN Doeswijk… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Peptide receptor scintigraphy and peptide receptor radionuclide therapy using radiolabeled
somatostatin receptor (SSTR) agonists are successfully used in the clinic for imaging and …
somatostatin receptor (SSTR) agonists are successfully used in the clinic for imaging and …
Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors
M Fani, A Mueller, ML Tamma, G Nicolas… - Journal of Nuclear …, 2010 - Soc Nuclear Med
A variety of radiolabeled somatostatin analogs have been developed for targeting of
somatostatin receptor (sst)–positive tumors. Bicyclic somatostatin-based radiopeptides have …
somatostatin receptor (sst)–positive tumors. Bicyclic somatostatin-based radiopeptides have …
Synthesis and evaluation of a 99mTc tricarbonyl-labeled somatostatin receptor-targeting antagonist peptide for imaging of neuroendocrine tumors
L Radford, F Gallazzi, L Watkinson, T Carmack… - Nuclear Medicine and …, 2017 - Elsevier
Introduction A somatostatin receptor (SSTR)-targeting antagonist peptide (sst 2-ANT) was
radiolabeled with 99m Tc tricarbonyl via a tridentate [N, S, N]-type ligand (L) to develop a …
radiolabeled with 99m Tc tricarbonyl via a tridentate [N, S, N]-type ligand (L) to develop a …
Radio‐guided surgery in neuroendocrine tumors
The majority of Neuroendocrine tumors (NET) express somatostatin (SS) receptors, and thus
can be successfully targeted with radiolabeled SS analogs in vivo. Somatostatin receptor …
can be successfully targeted with radiolabeled SS analogs in vivo. Somatostatin receptor …
Specific targeting of somatostatin receptor subtype-2 for fluorescence-guided surgery
Purpose: Clinically available intraoperative imaging tools to assist surgeons in identifying
occult lesions are limited and partially responsible for the high rate of disease recurrence in …
occult lesions are limited and partially responsible for the high rate of disease recurrence in …
A new radiolabelled somatostatin analogue [111In-DTPA-D-Phe1]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [111In-DTPA-D …
WAP Breeman, LJ Hofland, M Van der Pluijm… - European journal of …, 1994 - Springer
We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe 1] RC-
160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical …
160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical …