There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …

PURPOSE:: Desmoplastic small round cell tumors (DSRCTs) are rare aggressive neoplasms
that frequently present with large symptomatic intraabdominal masses. We examined the …

… Kushner, Kim Kramer, Shakeel Modak … Modak S, Cheung NK. Disialoganglioside
directed immunotherapy of neuroblastoma. Cancer Invest. … Kushner BH, Kramer K, Modak …

Survival outcomes for patients with high-risk neuroblastoma (NB) have significantly improved
with anti-disialoganglioside GD2 mAb therapy, which promotes NK cell activation through …

Innovation in the management of brain metastases is needed. We evaluated the addition of
compartmental intrathecal antibody-based radioimmunotherapy (cRIT) in patients with …

β-Glucan primes leukocyte CR3 for enhanced cytotoxicity and synergizes with anti-tumor
monoclonal antibodies (mAb). We studied readily available (1→3)-β-D-glucan using the …

Tumor-restricted surface antigens may be targets for diagnosis and immune-based therapies.
Monoclonal antibody 8H9 is a murine IgG1 hybridoma derived from the fusion of mouse …

Neuroblastoma, the most common extracranial pediatric solid tumor remains a clinical enigma
with outcomes ranging from cure in >90% of patients with locoregional tumors with little to …

BACKGROUND. The young age of neuroblastoma patients makes them especially prone to
the ototoxic effects of widely used treatments that feature aggressive use of platinum …

Introduction: Current therapeutic approaches for high-risk neuroblastoma (HR-NB) include
high-dose chemotherapy, surgery and radiotherapy; interventions that are associated with …