We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D)
in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-…

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D) 1 , 2 ; however, most of these loci have …

Chronic elevation of plasma aldosterone contributes to heart failure. Mineralocorticoid receptor
(MR) antagonism is cardioprotective in such a setting, but whether such protection occurs …

Light beams extending beyond the paraxial region are investigated by the correction scheme
of Lax et al. [ Phys. Rev. A11, 1365 ( 1975)] All higher-order corrections for the Laguerre–…

Background Although epidemiologic studies have suggested that several genetic variants
increase the risk of myocardial infarction, large-scale association studies that examine many …

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and
diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP …

Objectives. We investigated the usefulness of a new variable, oxygen uptake efficiency slope
(OUES), as a submaximal measure of cardiorespiratory functional reserve. The OUES is …

Multiple genetic loci associated with obesity or body mass index (BMI) have been identified
through genome-wide association studies conducted predominantly in populations of …

Background—Transforming growth factor-β (TGF-β) is an important regulator of vascular
remodeling and is involved in the pathogenesis of atherosclerosis. AT→C transition at …

Background— Mineralocorticoid receptor antagonism reduces mortality associated with heart
failure by mechanisms that remain unclear. The effects of the mineralocorticoid receptor …