Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

C Friesen, I Hormann, M Roscher, I Fichtner, A Alt… - Cell cycle, 2014 - Taylor & Francis
Glioblastoma are the most frequent and malignant human brain tumors, having a very poor
prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma …

PSMA-11–derived dual-labeled PSMA inhibitors for preoperative PET imaging and precise fluorescence-guided surgery of prostate cancer

…, M Schäfer, U Bauder-Wüst, M Roscher… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Resection of tumors using targeted dual-modality probes combining preoperative imaging
with intraoperative guidance is of high clinical relevance and might considerably affect the …

Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance

C Friesen, M Roscher, A Alt, E Miltner - Cancer research, 2008 - AACR
The therapeutic opioid drug methadone (d,l-methadone hydrochloride) is the most commonly
used maintenance medication for outpatient treatment of opioid dependence. In our study, …

[HTML][HTML] Cell death sensitization of leukemia cells by opioid receptor activation

C Friesen, M Roscher, I Hormann, I Fichtner, A Alt… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Cyclic AMP (cAMP) regulates a number of cellular processes and modulates cell death
induction. cAMP levels are altered upon stimulation of specific G-protein-coupled receptors …

[HTML][HTML] Inhibition of rho-associated kinase 1/2 attenuates tumor growth in murine gastric cancer

I Hinsenkamp, S Schulz, M Roscher, AM Suhr, B Meyer… - Neoplasia, 2016 - Elsevier
Gastric cancer (GC) remains a malignant disease with high mortality. Patients are frequently
diagnosed in advanced stages where survival prognosis is poor. Thus, there is high medical …

Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido-Type PSMA Inhibitors

J Cardinale, M Roscher, M Schäfer… - Journal of medicinal …, 2020 - ACS Publications
In recent years, a number of drugs targeting the prostate-specific membrane antigen (PSMA)
have become important tools in the diagnosis and treatment of prostate cancer. In the …

[HTML][HTML] Atomic nanogenerators in targeted alpha therapies: Curie's legacy in modern cancer management

M Roscher, G Bakos, M Benešová - Pharmaceuticals, 2020 - mdpi.com
Atomic in vivo nanogenerators such as actinium-225, thorium-227, and radium-223 are of
increasing interest and importance in the treatment of patients with metastatic cancer diseases…

The PSMA-11-derived hybrid molecule PSMA-914 specifically identifies prostate cancer by preoperative PET/CT and intraoperative fluorescence imaging

AC Eder, MA Omrane, S Stadlbauer, M Roscher… - European journal of …, 2021 - Springer
Resection of tumor tissue represents one of the standard curative treatment options for the
clinical management of prostate cancer [1]. However, intraoperative localization and precise …

[HTML][HTML] Targeted alpha-therapy using [Bi-213] anti-CD20 as novel treatment option for radio-and chemoresistant non-Hodgkin lymphoma cells

M Roscher, I Hormann, O Leib, S Marx, J Moreno… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Radioimmunotherapy (RIT) is an emerging treatment option for non-Hodgkin lymphoma (NHL)
producing higher overall response and complete remission rates compared with …

Investigation of tumor cells and receptor-ligand simulation models for the development of PET imaging probes targeting PSMA and GRPR and a possible crosstalk …

…, G Lambrinidis, E Tzortzini, M Roscher… - Molecular …, 2022 - ACS Publications
Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR)
have both been used in nuclear medicine as targets for molecular imaging and therapy of …