Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma
C Friesen, I Hormann, M Roscher, I Fichtner, A Alt… - Cell cycle, 2014 - Taylor & Francis
Glioblastoma are the most frequent and malignant human brain tumors, having a very poor
prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma …
prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma …
PSMA-11–derived dual-labeled PSMA inhibitors for preoperative PET imaging and precise fluorescence-guided surgery of prostate cancer
…, M Schäfer, U Bauder-Wüst, M Roscher… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Resection of tumors using targeted dual-modality probes combining preoperative imaging
with intraoperative guidance is of high clinical relevance and might considerably affect the …
with intraoperative guidance is of high clinical relevance and might considerably affect the …
Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance
C Friesen, M Roscher, A Alt, E Miltner - Cancer research, 2008 - AACR
The therapeutic opioid drug methadone (d,l-methadone hydrochloride) is the most commonly
used maintenance medication for outpatient treatment of opioid dependence. In our study, …
used maintenance medication for outpatient treatment of opioid dependence. In our study, …
[HTML][HTML] Cell death sensitization of leukemia cells by opioid receptor activation
C Friesen, M Roscher, I Hormann, I Fichtner, A Alt… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Cyclic AMP (cAMP) regulates a number of cellular processes and modulates cell death
induction. cAMP levels are altered upon stimulation of specific G-protein-coupled receptors …
induction. cAMP levels are altered upon stimulation of specific G-protein-coupled receptors …
[HTML][HTML] Inhibition of rho-associated kinase 1/2 attenuates tumor growth in murine gastric cancer
I Hinsenkamp, S Schulz, M Roscher, AM Suhr, B Meyer… - Neoplasia, 2016 - Elsevier
Gastric cancer (GC) remains a malignant disease with high mortality. Patients are frequently
diagnosed in advanced stages where survival prognosis is poor. Thus, there is high medical …
diagnosed in advanced stages where survival prognosis is poor. Thus, there is high medical …
Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido-Type PSMA Inhibitors
J Cardinale, M Roscher, M Schäfer… - Journal of medicinal …, 2020 - ACS Publications
In recent years, a number of drugs targeting the prostate-specific membrane antigen (PSMA)
have become important tools in the diagnosis and treatment of prostate cancer. In the …
have become important tools in the diagnosis and treatment of prostate cancer. In the …
[HTML][HTML] Atomic nanogenerators in targeted alpha therapies: Curie's legacy in modern cancer management
M Roscher, G Bakos, M Benešová - Pharmaceuticals, 2020 - mdpi.com
Atomic in vivo nanogenerators such as actinium-225, thorium-227, and radium-223 are of
increasing interest and importance in the treatment of patients with metastatic cancer diseases…
increasing interest and importance in the treatment of patients with metastatic cancer diseases…
The PSMA-11-derived hybrid molecule PSMA-914 specifically identifies prostate cancer by preoperative PET/CT and intraoperative fluorescence imaging
AC Eder, MA Omrane, S Stadlbauer, M Roscher… - European journal of …, 2021 - Springer
Resection of tumor tissue represents one of the standard curative treatment options for the
clinical management of prostate cancer [1]. However, intraoperative localization and precise …
clinical management of prostate cancer [1]. However, intraoperative localization and precise …
[HTML][HTML] Targeted alpha-therapy using [Bi-213] anti-CD20 as novel treatment option for radio-and chemoresistant non-Hodgkin lymphoma cells
M Roscher, I Hormann, O Leib, S Marx, J Moreno… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Radioimmunotherapy (RIT) is an emerging treatment option for non-Hodgkin lymphoma (NHL)
producing higher overall response and complete remission rates compared with …
producing higher overall response and complete remission rates compared with …
Investigation of tumor cells and receptor-ligand simulation models for the development of PET imaging probes targeting PSMA and GRPR and a possible crosstalk …
…, G Lambrinidis, E Tzortzini, M Roscher… - Molecular …, 2022 - ACS Publications
Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR)
have both been used in nuclear medicine as targets for molecular imaging and therapy of …
have both been used in nuclear medicine as targets for molecular imaging and therapy of …