Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the
lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging …

Insulinomas are neuroendocrine tumors arising from the pancreatic beta cells. Currently,
surgical resection is the therapy of choice, and therefore, preoperative localization of …

The Inveon small-animal PET scanner is characterized by a large, 127-mm axial length and
a 161-mm crystal ring diameter. The associated high sensitivity is obtained by using all lines …

For more than a decade, researchers have been trying to develop non-invasive imaging
techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of …

The positron emitters 18 F, 68 Ga, 124 I, and 89 Zr are all relevant in small-animal PET. Each
of these radionuclides has different positron energies and ranges and a different fraction of …

Aims/hypothesis A reliable method for in vivo quantification of pancreatic beta cell mass (BCM)
could lead to further insight into the pathophysiology of diabetes. The glucagon-like …

Purpose Insulinomas are neuroendocrine tumours derived from pancreatic β-cells. The
glucagon-like peptide 1 receptor (GLP-1R) is expressed with a high incidence (>90%) and high …

Purpose Radiolabelled peptides used for peptide receptor radionuclide therapy are excreted
mainly via the kidneys and are partly reabsorbed and retained in the proximal tubular cells. …

Background In single photon emission computed tomography [SPECT], high specific activity
of 111 In-labelled tracers will allow administration of low amounts of tracer to prevent …

Internalizing agonists are usually selected for peptide receptor targeting. There is increasing
evidence that non‐internalizing receptor antagonists can be used for this purpose. We …