[HTML][HTML] Eleven grand challenges in single-cell data science

…, JO Korbel, AM Kozlov, TH Kuo, BPF Lelieveldt… - Genome biology, 2020 - Springer
The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Conserved cell types with divergent features in human versus mouse cortex

…, RH Scheuermann, R Yuste, SM Sunkin, B Lelieveldt… - Nature, 2019 - nature.com
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

Deepeyes: Progressive visual analytics for designing deep neural networks

…, T Höllt, J Van Gemert, BPF Lelieveldt… - IEEE transactions on …, 2017 - ieeexplore.ieee.org
Deep neural networks are now rivaling human accuracy in several pattern recognition
problems. Compared to traditional classifiers, where features are handcrafted, neural networks …

An objective comparison of cell-tracking algorithms

…, J Jaldén, HM Blau, O Dzyubachyk, B Lelieveldt… - Nature …, 2017 - nature.com
We present a combined report on the results of three editions of the Cell Tracking Challenge,
an ongoing initiative aimed at promoting the development and objective evaluation of cell …

3-D active appearance models: segmentation of cardiac MR and ultrasound images

SC Mitchell, JG Bosch, BPF Lelieveldt… - IEEE transactions on …, 2002 - ieeexplore.ieee.org
A model-based method for three-dimensional image segmentation was developed and its
performance assessed in segmentation of volumetric cardiac magnetic resonance (MR) …

[HTML][HTML] Comparative cellular analysis of motor cortex in human, marmoset and mouse

…, CD Keene, PV Kharchenko, AL Ko, BP Lelieveldt… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

[HTML][HTML] Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease

DP Shamonin, EE Bron, BPF Lelieveldt… - Frontiers in …, 2014 - frontiersin.org
Nonrigid image registration is an important, but time-consuming task in medical image analysis.
In typical neuroimaging studies, multiple image registrations are performed, ie, for atlas-…

A new cluster validity index for the fuzzy c-mean

MR Rezaee, BPF Lelieveldt, JHC Reiber - Pattern recognition letters, 1998 - Elsevier
In this paper a new cluster validity index is introduced, which assesses the average
compactness and separation of fuzzy partitions generated by the fuzzy c-means algorithm. To …

Multistage hybrid active appearance model matching: segmentation of left and right ventricles in cardiac MR images

SC Mitchell, BPF Lelieveldt… - … on medical imaging, 2001 - ieeexplore.ieee.org
A fully automated approach to segmentation of the left and right cardiac ventricles from
magnetic resonance (MR) images is reported. A novel multistage hybrid appearance model …

Nonrigid image registration using multi-scale 3D convolutional neural networks

…, B De Vos, F Berendsen, BPF Lelieveldt… - … Image Computing and …, 2017 - Springer
In this paper we propose a method to solve nonrigid image registration through a learning
approach, instead of via iterative optimization of a predefined dissimilarity metric. We design a …