[HTML][HTML] Comparison of [18F]DCFPyL and [68Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer

…, M Schmidt, F Dietlein, BD Zlatopolskiy… - Molecular Imaging and …, 2015 - Springer
Purpose Gallium-68 (Ga-68)-labeled tracers for imaging expression of the prostate-specific
membrane antigen (PSMA) such as the [ 68 Ga]Ga-PSMA-HBED-CC have already …

PSA-stratified performance of 18F-and 68Ga-PSMA PET in patients with biochemical recurrence of prostate cancer

…, A Heidenreich, BD Zlatopolskiy… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Several studies outlined the sensitivity of 68 Ga-labeled PET tracers against the prostate-specific
membrane antigen (PSMA) for localization of relapsed prostate cancer in patients with …

Alcohol‐enhanced Cu‐mediated radiofluorination

…, B Neumaier, BD Zlatopolskiy - … –a European journal, 2017 - Wiley Online Library
The potential of many 18 F‐labeled (hetero)aromatics for applications in positron emission
tomography remains underexplored because convenient procedures for their radiosynthesis …

Copper‐mediated aromatic radiofluorination revisited: efficient production of PET tracers on a preparative scale

BD Zlatopolskiy, J Zischler, P Krapf… - … A European Journal, 2015 - Wiley Online Library
Two novel methods for copper‐mediated aromatic nucleophilic radiofluorination were recently
reported. Evaluation of these methods reveals that, although both are efficient in small‐…

Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18 F-labeling

…, EA Urusova, B Neumaier, BD Zlatopolskiy - Organic & …, 2014 - pubs.rsc.org
A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution
with [18F]fluoride is described. Different radiolabeled aliphatic and aromatic compounds …

Intraindividual comparison of 18F-PSMA-1007 with renally excreted PSMA ligands for PSMA PET imaging in patients with relapsed prostate cancer

…, C Kobe, M Hohberg, BD Zlatopolskiy… - Journal of nuclear …, 2020 - Soc Nuclear Med
18 F-prostate-specific membrane antigen (PSMA)-1007 is excreted mainly through the liver.
We benchmarked the performance of 18 F-PSMA-1007 against 3 renally excreted PSMA …

Discovery of 7-[18F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo

BD Zlatopolskiy, J Zischler, D Schäfer… - Journal of medicinal …, 2018 - ACS Publications
Tryptophan and its metabolites are involved in different physiological and pathophysiological
processes. Consequently, positron emission tomography (PET) tracers addressing …

Discovery of 18F-JK-PSMA-7, a PET probe for the detection of small PSMA-positive lesions

BD Zlatopolskiy, H Endepols, P Krapf… - Journal of nuclear …, 2019 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA), expressed by most prostate carcinomas (PCa),
is a promising target for PCa imaging. The application of PSMA-specific 18 F-labeled PET …

Convenient PET-tracer production via SuFEx 18F-fluorination of nanomolar precursor amounts

…, H Endepols, B Neumaier, BD Zlatopolskiy - European journal of …, 2022 - Elsevier
Recently, a protocol for radiolabeling of aryl fluorosulfates (“SuFEx click radiolabeling”) using
ultrafast 18 F/ 19 F isotopic exchange has been reported. Although promising, the original …

[HTML][HTML] Drug penetration into the central nervous system: pharmacokinetic concepts and in vitro model systems

F Neumaier, BD Zlatopolskiy, B Neumaier - Pharmaceutics, 2021 - mdpi.com
Delivery of most drugs into the central nervous system (CNS) is restricted by the blood–brain
barrier (BBB), which remains a significant bottleneck for development of novel CNS-…