Background Neuroimaging studies provide strong evidence that the pathophysiology of
obsessive-compulsive disorder (OCD) involves abnormal functioning along specific frontal-…

Background In functional brain imaging studies of major depressive disorder (MDD), regional
abnormalities have been most commonly found in prefrontal cortex, anterior cingulate …

Background In functional brain imaging studies, exposure to cues related to cocaine, opiates,
and alcohol in dependent individuals is associated with activation of the anterior cingulate …

OBJECTIVE: Compulsive hoarding and saving symptoms, found in many patients with
obsessive-compulsive disorder (OCD), are part of a discrete clinical syndrome that includes …

Previous positron emission tomography (PET) studies of patients with obsessive-compulsive
disorder (OCD) have found elevated glucose metabolic rates in the orbitofrontal cortex (OFC…

BACKGROUND: Magnetic resonance imaging (MRI) studies have demonstrated large-scale
brain abnormalities in cigarette smokers, such as ventricular enlargement and atrophy. …

Context 2-[ 18 F]fluoro-3-(2(S)-azetidinylmethoxy) pyridine (2-FA-85380, abbreviated as 2-FA)
is a recently developed radioligand that allows for visualization of brain α 4 β 2 * nicotinic …

While methamphetamine addiction has been associated with both impulsivity and striatal
dopamine D 2 /D 3 receptor deficits, human studies have not directly linked the latter two …

OBJECTIVE: Substantial evidence from animal models demonstrates that dopamine release
in the ventral striatum underlies the reinforcing properties of nicotine. The authors used [ 11 …

In subjects with obsessive-compulsive disorder (OCD), lower pre-treatment metabolism in the
right orbitofrontal cortex (OFC) and anterior cingulate gyrus (AC) has been associated with …