Demographic, Clinical, and Biomarker Characteristics of Sample
| P* | |||||
| Characteristic | CU young | CU elderly | CI | CU youngvs.CU elderly | CU elderlyvs.CI |
| Total patients (n) | 22 | 89 | 65 | — | — |
| Mean age (y) | 22.7 (SD, 1.3) | 72.33 (SD, 5.88) | 67.91 (SD, 8.97) | <0.0001 | 0.0004 |
| Female (n) | 14 (63%) | 51 (57%) | 36 (55%) | 0.59 | 0.81 |
| Mean education (y) | 16.61 (SD, 1.33) | 15.06 (SD, 3.81) | 15.1 (SD, 3.34) | 0.06 | 0.94 |
| APOEε4 carriers (n) | 6 (27%) | 33 (37%) | 41 (63%) | 0.58 | <0.0001 |
| Mean MMSE | 29.77 (SD, 0.53) | 29.12 (SD, 1.07) | 24.03 (SD, 6.07) | 0.009 | <0.0001 |
| Mean neocortical 18F-AZD4694 SUVR | 1.14 (SD, 0.09) | 1.48 (0.38) | 2.04 (SD, 0.57) | <0.0001 | <0.0001 |
| Mean CSF Aβ42/Aβ40 | 0.09 (SD, 0.006) | 0.07 (SD, 0.02) | 0.05 (SD, 0.02) | <0.0001 | <0.0001 |
↵* Assessed with 2-sided independent-samples t tests for each variable except sex and APOEε4 status, for which contingency χ2 tests were performed.
MMSE = Mini-Mental State Examination.