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A 0.25-mm-diameter probe, simulated here, has been established as sufficiently sensitive for use in studies of PET tracer binding in the mouse brain. This probe, a new technical adaptation, will be invaluable for studies of serotonergic function in conventional or knock-out models of depression. The methodology can be used to address a wide range of issues relevant to the PET exploration of neurotransmitter systems in mouse models of neurologic or psychiatric diseases.
See page 1159.
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