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RGD-PEG conjugation effectively modifies Ad vector tropism to improve systemic gene delivery. ¹⁸F-FHBG PET can monitor the transfectivity of both Adtk and RGD-PEG-Adtk vectors in vivo and appears appropriate for monitoring the efficacy of chemically modified HSV1-sr39tk/ganciclovir suicide gene therapy.
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