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ON THE COVER

This patient was judged as showing positive findings on ₉₉mTc-scintigraphy. Despite the small size of the tumor (green arrow), regional lymph nodes are detectable (red arrow), reflecting an active immune response inside the primary and metastatic tumors. The target-to-background radioactivity ratio is 1.44. CD25 staining shows a mild positivity for neoplastic cells and a strong, diffuse positivity for lymphocytes..