Discussions with leaders: JNM editor-in-chief Johannes Czernin continues a series of interviews with leaders in nuclear and molecular imaging and therapy with a conversation with Nora Volkow.
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Medical treatment of GEP NETS: Mohamed and Strosberg provide an overview of advances in medical management of gastroenteropancreatic neuroendocrine tumors within the context of the larger multidisciplinary approach to these diseases.
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Imaging the heart–brain axis: Thackeray offers a look at recent work underlining the still-to-be-elucidated connections between neuroinflammation/long-term brain function and ischemic injury to the heart.
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Cell therapy imaging: Martinez and colleagues highlight key developments over the last 5 years in cell-based cancer therapies, including the introduction of novel tracers for in vivo tracking.
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Imaging agent/modality translation: Gambhir and other participants report on a 2017 National Cancer Institute–led meeting of government, professional, and industry groups on phase III studies and pathways of approval, coverage, and reimbursement for new cancer imaging agents and modalities.
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Dynamic PET/CT in PPGLs: Berkel and colleagues use dynamic 18F-FDG PET/CT imaging to assess whether in vivo 18F-FDG pharmacokinetic assessment offers added value over static PET to distinguish different genotypes in pheochromocytomas and paragangliomas.
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Tumor lysis syndrome after RLT: Huang and colleagues describe the occurrence of tumor lysis syndrome after radioligand therapy with 177Lu-labeled agents in patients with neuroendocrine tumors and prostate cancer.
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Fluorescence-guided surgery: Liu and Sanai provide perspective on current approaches, trends, and challenges to the clinical adoption of fluorescence-guided surgery and intraoperative decision making and preview a related article in this issue of JNM.
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Real-time fluorescence-guided surgery: van Keulen and colleagues assess the clinical utility of real-time fluorescence imaging for intraoperative decision making in patients with head and neck squamous cell carcinoma.
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Tongue cancer tumor margins: Meershoek and colleagues explore the utility of an indocyanine green–99mTc-nanocolloid tracer for tumor margin demarcation combined with sentinel node biopsy in patients with oral tongue tumors.
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Characterizing thyroid cancer: De Rose and colleagues validate galectin-3 targeting as a method to detect non–radioiodine-avid thyroid cancer in thyroid orthotopic tumor models and discuss potential advantages over thyroid scintigraphy in distinguishing malignant from benign lesions.
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64Cu-SARTATE in NETs: Hicks and colleagues perform a first-in-humans trial of PET/CT imaging with this novel somatostatin analog in patients with neuroendocrine neoplasia to assess its safety and ability to localize disease at early and late imaging time-points.
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68Ga-PSMA-11 metaanalysis: Hope and colleagues detail an updated metaanalysis of reports on 68Ga-PSMA-11 PET staging in prostate cancer, separating imaging at the time of diagnosis from that at biochemical recurrence and focusing on pathology correlation.
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PET and MR imaging in PCa: Emmett and colleagues assess the ability of 18F-FCH PET/CT, 68Ga-HBED-CC PSMA-11 PET/CT, and pelvic multiparametric MR imaging to identify men with prostate cancer who will best benefit from salvage radiation treatment.
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68Ga-FAPI PET/CT tumor SUV: Kratochwil and colleagues quantify uptake of a 68Ga-labeled fibroblast-activation-protein inhibitor on PET/CT in various primary and metastatic tumors to identify the most promising indications for future application.
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Clinical experience with 90Y-PSMA: Rathke and colleagues present dosimetry estimates for 90Y-labeled prostate-specific membrane antigen–617, report first clinical experiences, and discuss advantages and drawbacks of varying the β-emitter in PSMA-targeting radioligand therapy.
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Exendin-4 for insulinoma therapy: Buitinga and colleagues evaluate the ability of succinylated gelatin to reduce renal accumulation of radiolabeled exendin and estimate maximum absorbed insulinoma doses if exendin were used for peptide-receptor radionuclide therapy.
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18F-JK-PSMA-7 for PSMA-positive lesions: Zlatopolskiy and colleagues describe development of this highly selective prostate-specific membrane antigen probe and its enhanced imaging properties, with comparisons to 18F-DCFPyL, 18F-PSMA-1007, and 68Ga-PSMA-11.
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Patient positioning for cardiac SPECT: Perrin and colleagues report on results of a study assessing myocardial perfusion imaging in a forward-leaning bikerlike position with the high-sensitivity D.SPECT cadmium-zinc-telluride camera.
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Data-driven GPM detection and correction: Lassen and colleagues investigate the feasibility of an automated data-driven method for detection of gross patient motion during coronary PET acquisition.
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AD conversion–related network: Blazhenets and colleagues use a principal components analysis to identify a metabolic Alzheimer disease conversion–related pattern in PET data from individuals with mild cognitive impairment and investigate the prognostic value of resulting pattern expression scores.
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Reproducibility of awake mouse brain PET: Miranda and colleagues develop and validate brain PET imaging techniques for awake, freely moving mice, with radioactive point-source markers used to track head motion for correction.
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MR and PET/MR index in Crohn’s disease: Li and colleagues describe an 18F-FDG PET/MR enterography index as a hybrid surrogate marker for active ileocolonic inflammation in Crohn’s disease and compare its diagnostic performance with that of validated MR indices.
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Innate immuno-PET in colitis: Dmochowska and colleagues compare immuno-PET of antibodies to IL-1β and CD11b against standard 18F-FDG and MR imaging approaches in detection of colonic inflammation.
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PET radiomics optimization: Papp and colleagues report on a radiomics analysis of 18F-FDG PET data to identify feature extraction and imaging protocol parameters that minimize radiomic feature variations across PET imaging systems.
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- © 2019 by the Society of Nuclear Medicine and Molecular Imaging.