Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleClinical Investigations

18F-FDG PET Is an Early Predictor of Overall Survival in Suspected Atypical Parkinsonism

Sabine Hellwig, Lars Frings, Florian Amtage, Ralph Buchert, Timo S. Spehl, Michel Rijntjes, Oliver Tüscher, Cornelius Weiller, Wolfgang A. Weber, Werner Vach and Philipp T. Meyer
Journal of Nuclear Medicine October 2015, 56 (10) 1541-1546; DOI: https://doi.org/10.2967/jnumed.115.159822
Sabine Hellwig
1Department of Neurology, University Hospital of Freiburg, Freiburg, Germany
2Centre of Geriatrics and Gerontology, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lars Frings
2Centre of Geriatrics and Gerontology, University Hospital of Freiburg, Freiburg, Germany
3Department of Nuclear Medicine, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Florian Amtage
1Department of Neurology, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph Buchert
4Department of Nuclear Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timo S. Spehl
3Department of Nuclear Medicine, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michel Rijntjes
1Department of Neurology, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oliver Tüscher
1Department of Neurology, University Hospital of Freiburg, Freiburg, Germany
5Department of Psychiatry, University Hospital Mainz, Mainz, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cornelius Weiller
1Department of Neurology, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wolfgang A. Weber
6Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Werner Vach
7Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, University of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philipp T. Meyer
3Department of Nuclear Medicine, University Hospital of Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Abstract

Early prognostic stratification is desirable in patients with suspected atypical parkinsonian syndromes (APSs) for optimal treatment and counseling. We investigated the prognostic value of imaging disease-specific metabolism patterns with 18F-FDG PET compared with that of clinical diagnosis. Methods: Seventy-eight patients with suspected APS at study inclusion underwent a follow-up of up to 5.9 y after prospective 18F-FDG PET imaging. Survival data were analyzed by Kaplan–Meier and Cox regression analyses according to diagnostic classifications provided by 18F-FDG PET at baseline and clinical diagnoses after a median follow-up of 1 y after PET. Results: Forty-four of 78 patients were alive 4.7 ± 0.6 y after PET. Patients diagnosed with an APS by PET or 1-y clinical follow-up showed a significantly shorter median survival time (4.1 y, age-adjusted hazard ratios [HRs] = 3.8 for both classifiers) than those diagnosed with Lewy-body diseases (LBDs; majority Parkinson disease [PD]; median survival time not reached). Subgroup classifications of progressive supranuclear palsy/corticobasal degeneration (PSP/CBD) or multiple-system atrophy (MSA) by PET and clinical follow-up were associated with significantly shorter survival than PD. Age-adjusted mortality was significantly increased for PSP/CBD (HR = 5.2) and MSA (HR = 5.6) classified by PET, but for PSP/CBD only when diagnosed by clinical follow-up (HR = 4.5). Patients with a PET pattern suggestive of PD with dementia/dementia with Lewy bodies (PDD/DLB) exhibited a trend toward shorter survival than those with PD (P = 0.07), whereas patients classified as PDD/DLB by clinical follow-up did not (P = 0.65). Conclusion: 18F-FDG PET is an early predictor of survival in patients with clinically suspected APS. Detection of cortical or subcortical hypometabolism by 18F-FDG PET is an unfavorable predictor. Risk stratification by 18F-FDG PET appears to be at least as predictive as the 1-y follow-up clinical diagnosis. This finding strongly supports the early inclusion of PET imaging in patient care.

  • 18F-FDG PET
  • survival
  • prognosis
  • parkinsonism
  • atypical parkinsonian syndrome

Footnotes

  • Published online Jul. 30, 2015.

  • © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
View Full Text
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 56 (10)
Journal of Nuclear Medicine
Vol. 56, Issue 10
October 1, 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
18F-FDG PET Is an Early Predictor of Overall Survival in Suspected Atypical Parkinsonism
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
18F-FDG PET Is an Early Predictor of Overall Survival in Suspected Atypical Parkinsonism
Sabine Hellwig, Lars Frings, Florian Amtage, Ralph Buchert, Timo S. Spehl, Michel Rijntjes, Oliver Tüscher, Cornelius Weiller, Wolfgang A. Weber, Werner Vach, Philipp T. Meyer
Journal of Nuclear Medicine Oct 2015, 56 (10) 1541-1546; DOI: 10.2967/jnumed.115.159822

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
18F-FDG PET Is an Early Predictor of Overall Survival in Suspected Atypical Parkinsonism
Sabine Hellwig, Lars Frings, Florian Amtage, Ralph Buchert, Timo S. Spehl, Michel Rijntjes, Oliver Tüscher, Cornelius Weiller, Wolfgang A. Weber, Werner Vach, Philipp T. Meyer
Journal of Nuclear Medicine Oct 2015, 56 (10) 1541-1546; DOI: 10.2967/jnumed.115.159822
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • Early atypical signs and insula hypometabolism predict survival in multiple system atrophy
  • Predictors of survival in frontotemporal lobar degeneration syndromes
  • 18F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment
  • Predictors of survival in progressive supranuclear palsy and multiple system atrophy: a systematic review and meta-analysis
  • Google Scholar

More in this TOC Section

  • Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  • Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
  • Validation and Evaluation of a Vendor-Provided Head Motion Correction Algorithm on the uMI Panorama PET/CT System
Show more Clinical Investigations

Similar Articles

Keywords

  • 18F-FDG PET
  • survival
  • prognosis
  • parkinsonism
  • atypical parkinsonian syndrome
SNMMI

© 2025 SNMMI

Powered by HighWire