Abstract
Imaging of expression of therapeutic targets may enable patients’ stratification for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain-only immunoglobulins or non-immunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini-review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of oncology.
- Animal Imaging
- Molecular Imaging
- Oncology: Breast
- affibody
- nanobody
- radionuclide molecular imaging
- scaffold proteins
- Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.