Abstract
Myocardial blood flow (MBF) and flow reserve (MFR) measured with positron emission tomography (PET) have clinical value. Single-photon emission computed tomography (SPECT) cameras with solid-state detectors can obtain dynamic images for measurement of MBF and MFR. In this study, SPECT measurements of MBF made using 99mTc-tetrofosmin were compared to PET in the same patients. Methods: Thirty-one patients had PET MBF rest-stress studies performed with 82Rb or 13N- ammonia within one month of their SPECT. Dynamic rest-stress measurements were made using a SPECT camera. Kinetic parameters were calculated using a 1-tissue-compartment model and converted to MBF and MFR. Processing with and without corrections for attenuation (±AC), patient body motion (±MC) and binding of the tracer to red blood cells (±BB) was evaluated. Results: Both +BB and +MC improved the accuracy and precision of global SPECT MBF compared to PET MBF resulting in an average difference of 0.06 ± 0.37 mL/min/g. Global MBF and detection of abnormal MFR were not significantly improved with +AC. Global SPECT MFR with +MC and +BB had an area under the receiver operating curve (AROC) of 0.90 (+AC) to 0.95 (-AC) for detecting abnormal PET MFR < 2.0. Regional analysis produced similar results with an AROC of 0.84 (+AC) to 0.87 (-AC). Conclusion: Solid-state SPECT provides global MBF and MFR measurements that differ from PET by 2% ± 32% (MBF) and 2% ± 28% (MFR).
- Cardiology (clinical)
- Image Processing
- SPECT
- PET myocardial blood flow
- SPECT myocardial blood flow
- attenuation correction
- cadmium zinc telluride
- Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.