Abstract
Purpose: In this study the performance of various methods for generating quantitative parametric images of dynamic 11C-phenytoin PET studies will be evaluated. Methods: Double baseline 60 min dynamic 11C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method (BFM) and spectral analysis (SA). Parametric distribution volume (VT) and influx rate (K1) were compared to those obtained from non-linear regression (NLR) analysis of time activity curves. In addition, global and regional test-retest (TRT) variability was determined for parametric K1 and VT values. Results: Biases in VT observed with all parametric methods were less than 5%, For K1, SA showed negative bias of 16%. Mean TRT variabilities of VT and K1 were less than 10% for all methods. Shortening the scan duration to 45 min provided similar VT and K1 with comparable TRT performance compared to 60 min data. Conclusion: Among the various parametric methods tested, BFM provided parametric VT and K1 values with the least bias compared to NLR data and showed TRT variabilities lower than 5%, also for smaller VOI sizes (i.e. higher noise levels) and shorter scan duration.
- Molecular Imaging
- PET/CT
- Radiotracer Tissue Kinetics
- 11C-Phenytoin
- PET quantification
- parametric kinetic modelling
- test-retest variability
- Copyright © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.