Abstract
This study compared the DNM-530c (GE Healthcare) and DSPECT (Biosensors International) to a conventional Anger camera with cardiofocal collimators (Symbia IQ, Siemens) for left ventricular (LV) function assessment in phantom and patients. Methods: The Amsterdam gated (AGATE) dynamic cardiac phantom (Vanderwilt techniques, Boxtel, The Netherlands) was used. Eighteen acquisitions were processed on each CZT and Anger (IQ SPECT) camera. The total number of counts varied from 0.25 kcts to 1.5 Mcts within a myocardial VOI. Ejection fraction (EF) was set to 33%, 45% or 60%. Volumes, ejection fraction (LVEF), regional wall thickening and motion (17-segment model) were assessed using QGS (Cedars-Sinaï). One hundred and twenty patients with low pretest likelihood of coronary artery disease and normal stress perfusion SPECT were retrospectively analyzed to provide the normal limits for EDV, ESV, EF and regional function for each camera model. Results: In the phantom study, for each EF value, volumes were higher using the DNM-530c and DSPECT cameras compared to IQ SPECT, resulting in decreased but more accurate LVEF (all P<0.001). In clinical data, body-surface indexed ventricular volumes were higher using the DNM-530c compared to DSPECT and IQ SPECT [respectively EDVi (mL/m2): 40.5±9.2, 37±7.9 and 35.8±6.8 (P<0.001), ESVi (mL/m2): 12.5±5.3, 9.4±4.2 and 8.3±4.4 (P<0.001)], resulting in a significantly decreased LVEF (%): 70.3±9.1 vs. 75.2±8.1 vs. 77.8±9.3 (P <0.001). Conclusion: New CZT cameras yielded different results of global LV function compared to Anger camera with cardiofocal collimators. In our study, LV volumes were higher using the DNM 530c compared to DSPECT and IQ SPECT, leading to decreased LVEF in normal subjects. These differences should be taken into account in clinical practice and warrant the collection of specific normal database.
- Cardiology (basic/technical)
- Cardiology (clinical)
- SPECT
- CZT
- cardiofocal collimators
- left ventricular function
- myocardial perfusion imaging
- wall thickening
- Copyright © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.