JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS
QUICK SEARCH:   [advanced]


     

First published online May 14, 2009
J Nucl Med 2009, doi:10.2967/jnumed.108.061432
 © 2009 by Society of Nuclear Medicine
This Article
Right arrow Full Text (Publish Ahead of Print[PDF])
Right arrow All Versions of this Article:
jnumed.108.061432v1
50/6/854    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Menezes, L. J.
Right arrow Articles by Groves, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Menezes, L. J.
Right arrow Articles by Groves, A. M.

Vascular Inflammation Imaging with 18F-FDG PET/CT: When to Image?

Leon J. Menezes 1, Carl W. Kotze 2, Brian F. Hutton 1, Raymondo Endozo 1, John C. Dickson 1, Ian Cullum 1, Syed W. Yusuf 2, Peter J. Ell 1, and Ashley M. Groves 1*

1 Institute of Nuclear Medicine, University College Hospital, University College London, London, United Kingdom
2 Brighton and Sussex University Hospital, Brighton, Sussex, United Kingdom

* To whom correspondence should be addressed. E-mail: drashleygroves{at}hotmail.com.


  Abstract

We prospectively investigated the ideal imaging time to measure vascular uptake after injection of 18F-FDG. Methods: A total of 17 patients with atherosclerotic abdominal aortic aneurysm underwent dynamic abdominal PET/CT using 2-min frames between 45 and 53, 57 and 65, 115 and 123, and 175 and 183 min after injection of 18F-FDG. For each period of dynamic imaging, vessel wall and lumen uptake were measured using the maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR). Results: No significant difference in TBR across all time points (repeated measures ANOVA, P = 0.206) was observed, despite a significant difference in aortic wall and lumen uptake with time (repeated measures ANOVA, P = 0.02 and P < 0.001, respectively). There was no significant difference between aortic wall uptake at 60 min (SUVmax, 2.15 ± 0.11 SE) and 180 min (SUVmax, 1.99 ± 0.18 SE) (paired t test, P = 0.367). There was a significant difference in lumen uptake at 60 min (SUVmax, 2.4 ± 0.11 SE) and 180 min (SUVmax, 1.7 ± 0.1 SE) (paired t test, P = 0.001). There was no significant difference in TBR between 60 min (0.91 ± 0.03) and 180 min (1.01 ± 0.06 SE) (paired t test, P = 0.131). With increasing delayed imaging, there was increasing variability (SE) in the SUVmax for the aortic wall and TBRs. Conclusion: There was no significant advantage in imaging at 3 h over 1 h after 18F-FDG injection.

Key Words: PET/CT, vascular, radiotracer tissue kinetics, 18F-FDG, aneurysm, atherosclerosis, methodology, positron emission tomography




This article has been cited by other articles:


Home page
 JNMHome page
J. H.F. Rudd, M. Elkhawad, and Z. A. Fayad
Vascular Imaging with 18F-FDG PET/CT: Optimal 18F-FDG Circulation Time?
J. Nucl. Med., September 1, 2009; 50(9): 1560 - 1560.
[Full Text] [PDF]

Home page
 JNMHome page
C. W. Kotze, S. W. Jusuf, L. J. Menezes, B. F. Hutton, P. J. Ell, and A. M. Groves
Reply: Vascular Imaging with 18F-FDG PET/CT: Optimal 18F-FDG Circulation Time?
J. Nucl. Med., September 1, 2009; 50(9): 1560 - 1561.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2009 by the Society of Nuclear Medicine.