Imaging of Inflamed and Vulnerable Plaque in Coronary Arteries with ¹⁸F-FDG PET/CT in Patients with Suppression of Myocardial Uptake Using a Low-Carbohydrate, High-Fat Preparation

¹ Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Interventional Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
² Division of Nuclear Medicine, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
³ Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

^* To whom correspondence should be addressed. E-mail: rlaham{at}bidmc.harvard.edu.

	Abstract

PET/CT imaging with ¹⁸F-FDG has been used to detect inflammation in carotid and aortic plaque; its use in detecting coronary plaque has been limited by avid ¹⁸F-FDG uptake by the myocardium. We investigated whether ¹⁸F-FDG PET/CT could be used to image inflammation in coronary arteries as a potential noninvasive method to detect vulnerable plaque. Methods: We retrospectively studied 32 patients treated for malignancy who underwent ¹⁸F-FDG PET/CT and concomitant cardiac catheterization. As part of the recently described protocol, all patients were instructed to eat a low-carbohydrate, high-fat meal the night before and drink a vegetable oil drink the morning of the study. We reviewed the patients' baseline characteristics and their ¹⁸F-FDG PET/CT scans for adequacy of myocardial uptake suppression and correlated the presence of angiographically apparent plaque with ¹⁸F-FDG uptake in the major coronary arteries. Two independent observers assessed the angiographic images and ¹⁸F-FDG PET scans. Results: A total of 95% of patients had 2 or more coronary disease risk factors, and 25% had unstable symptoms; 30% of index catheterizations resulted in intervention. In 20 of 32 patients (63%), myocardial suppression was good (12) or adequate (8). Inadequate suppression was due to self-reported dietary nonadherence. Patients with good, adequate, and poor suppression had maximal myocardial standardized uptake values of 2.8 ± 0.7, 5.0 ± 1.3, and 17.0 ± 9.7, respectively. We identified ¹⁸F-FDG uptake in 15 patients in 1 or more coronary segments. A trend to significance in correlation between presence of angiographic disease and signal in the vessel was observed (P = 0.07; 80 vessels examined). A total of 7 patients with significant coronary artery disease had aortic ¹⁸F-FDG uptake. Conclusion: In this retrospective study, we demonstrated the potential use of ¹⁸F-FDG PET in imaging of inflammation in coronary arteries. The potential of ¹⁸F-FDG PET is also being investigated in a prospective study.

Key Words: vulnerable plaque, ¹⁸F-FDG PET/CT, imaging, coronary

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