Motion-Frozen Myocardial Perfusion SPECT Improves Detection of Coronary Artery Disease in Obese Patients
Yasuyuki Suzuki 1,
Piotr J. Slomka 2*,
Arik Wolak 1,
Muneo Ohba 1,
Shoji Suzuki 1,
Ling De Yang 1,
Guido Germano 2,
and
Daniel S. Berman 2
1 Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, California
2 Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California
* To whom correspondence should be addressed. E-mail: piotr.slomka{at}cshs.org.
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Abstract |
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In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1–46.8, average, 34.3 ± 3.6; age, 63 ± 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3 mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.
Key Words:
gated SPECT, myocardial perfusion, image registration, image warping, coronary artery disease, motion correction
