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First published online July 16, 2008
J Nucl Med 2008, doi:10.2967/jnumed.107.050195
 © 2008 by Society of Nuclear Medicine
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SPECT/CT

Andreas K. Buck 1*, Stephan Nekolla 1, Sibylle Ziegler 1, Ambros Beer 1, Bernd J. Krause 1, Ken Herrmann 1, Klemens Scheidhauer 1, Hans-Juergen Wester 1, Ernst J. Rummeny 2, Markus Schwaiger 1, and Alexander Drzezga 1

1 Department of Nuclear Medicine, Technische Universität München, München, Germany
2 Department of Radiology, Technische Universität München, München, Germany

* To whom correspondence should be addressed. E-mail: andreas.buck{at}tum.de.


  Abstract

In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT in combination with CT enables a direct correlation of anatomic information and functional information, resulting in better localization and definition of scintigraphic findings. Besides anatomic referencing, the added value of CT coregistration is based on the attenuation correction capabilities of CT. The number of clinical studies is limited, but pilot studies have indicated a higher specificity and a significant reduction in indeterminate findings. The superiority of SPECT/CT over planar imaging or SPECT has been demonstrated in bone scintigraphy, somatostatin receptor scintigraphy, parathyroid scintigraphy, and adrenal gland scintigraphy. Also, rates of detection of sentinel nodes by biopsy can be increased with SPECT/CT. This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications.

Key Words: scintigraphy, SPECT, CT, PET, hybrid imaging




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B. L. Judson and A. R. Shaha
Nuclear Imaging and Minimally Invasive Surgery in the Management of Hyperparathyroidism
J. Nucl. Med., November 1, 2008; 49(11): 1813 - 1818.
[Abstract] [Full Text] [PDF]


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