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First published online December 12, 2007
J Nucl Med 2007, doi:10.2967/jnumed.107.045799
 © 2007 by Society of Nuclear Medicine
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Optical Imaging: Current Applications and Future Directions

Gary D. Luker 1* and Kathryn E. Luker 1

1 University of Michigan, Ann Arbor, Michigan

* To whom correspondence should be addressed. E-mail: gluker{at}umich.edu.


  Abstract

Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. Whereas optical imaging has been used primarily for research in small-animal models, there are several areas in which optical molecular imaging will translate to clinical medicine. In this review, we summarize recent advances in optical techniques for molecular imaging and the potential impact for clinical medicine.

Key Words: bioluminescence imaging, fluorescence imaging, optical imaging probes




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