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First published online April 15, 2008, 10.2967/jnumed.107.048074
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Journal of Nuclear Medicine Vol. 49 No. 5 752-756
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.107.048074

Clinical Investigation

Visualization of Brown Adipose Tissue with 99mTc-Methoxyisobutylisonitrile on SPECT/CT

Sibyll Goetze, William C. Lavely, Harvey A. Ziessman and Richard L. Wahl

Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland

Correspondence: For correspondence or reprints contact: Richard L. Wahl, Division of Nuclear Medicine/PET, 601 N. Caroline St., Room 3223A., Baltimore, MD 21287-0817. E-mail: rwahl{at}jhmi.edu

Brown adipose tissue (BAT) is retained into adulthood in some patients. It has been imaged using several radiopharmaceuticals, including 18F-FDG. Using SPECT/CT, we assessed whether and how frequently uptake of 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) was present in expected locations of BAT. Methods: A total of 205 SPECT/CT scans using 99mTc-MIBI for parathyroid imaging were reviewed for the presence of 99mTc-MIBI uptake in expected locations of BAT. Results: We detected 99mTc-MIBI uptake in BAT in 13 of 205 patients (6.3%). When BAT was visualized, it was detected on both early and delayed scans. The patients with 99mTc-MIBI uptake in BAT were younger than the patients with no 99mTc-MIBI uptake (P = 0.044). Conclusion: Uptake of 99mTc-MIBI in BAT is relatively common in this adult patient population and should not be confused with 99mTc-MIBI-avid–tumors. SPECT/CT can be useful for defining such tracer uptake as a normal physiologic variant.

Key Words: brown adipose tissue • hybrid imaging • 99mTc-methoxyisobutylisonitrile • SPECT/CT

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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