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First published online January 16, 2008, 10.2967/jnumed.107.045526
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Journal of Nuclear Medicine Vol. 49 No. 2 255-259
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.107.045526

Brief Communication

Patterns of {alpha}vβ3 Expression in Primary and Metastatic Human Breast Cancer as Shown by 18F-Galacto-RGD PET

Ambros J. Beer1, Markus Niemeyer2, Janette Carlsen1, Mario Sarbia3, Jörg Nährig3, Petra Watzlowik1, Hans-Jürgen Wester1, Nadia Harbeck2 and Markus Schwaiger1

1 Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; 2 Department of Gynecology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; and 3 Department of Pathology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

Correspondence: For correspondence or reprints contact: Ambros J. Beer, MD, Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany. E-mail: beer{at}roe.med.tum.de

The integrin {alpha}vβ3 is a key player in angiogenesis and metastasis. Our aim was to study the uptake patterns of the {alpha}vβ3-selective PET tracer 18F-galacto-RGD in invasive ductal breast cancer. Methods: Sixteen patients with primary (n = 12) or metastasized breast cancer (n = 4) were examined with 18F-galacto-RGD PET. Standardized uptake values (SUVs) were derived by region-of-interest analysis, and immunohistochemistry of {alpha}vβ3 expression was performed (n = 5). Results: 18F-Galacto-RGD PET identified all invasive carcinomas, with SUVs from 1.4 to 8.7 (mean ± SD, 3.6 ± 1.8; tumor-to-blood and tumor-to-muscle ratios, 2.7 ± 1.6 and 6.2 ± 2.2, respectively). Lymph-node metastases were detected in 3 of 8 patients (mean SUV, 3.3 ± 0.8). SUVs in distant metastases were heterogeneous (2.9 ± 1.4). Immunohistochemistry confirmed {alpha}vβ3 expression predominantly on microvessels (5/5) and, to a lesser extent, on tumor cells (3/5). Conclusion: Our results suggest generally elevated and highly variable {alpha}vβ3 expression in human breast cancer lesions. Consequently, further imaging studies with 18F-galacto-RGD PET in breast cancer patients for assessment of angiogenesis or planning of {alpha}vβ3-targeted therapies are promising.

Key Words: breast cancer • integrins • {alpha}vβ3 • angiogenesis • PET • RGD

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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