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First published online October 17, 2007, 10.2967/jnumed.107.046037
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Journal of Nuclear Medicine Vol. 48 No. 11 1796-1799
© 2007 by Society of Nuclear Medicine
doi: 10.2967/jnumed.107.046037

Brief Communication

An Implantable Synthetic SPECT Lesion: A Bridge from Phantom to Reality

M. Bret Abbott, Lars R. Furenlid, Don W. Wilson, Gail D. Stevenson, James M. Woolfenden and Harrison H. Barrett

Center for Gamma-Ray Imaging, Department of Radiology, University of Arizona, Tucson, Arizona

Correspondence: For correspondence or reprints contact: M. Bret Abbott, MD, PhD, c/o Corrie Thies, Department of Radiology, P.O. Box 245067, Tucson, Arizona 85724-5067. E-mail: mbamdphd{at}yahoo.com

Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. Methods: Anion-exchange columns with bed volumes of 100–300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system. Results: Activity of 7.4–22.2 MBq (0.2–0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk. Conclusion: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.

Key Words: small-animal SPECT • phantom • synthetic lesion • implantable device

COPYRIGHT © 2007 by the Society of Nuclear Medicine, Inc.


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