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The Journal of Nuclear Medicine Vol. 27 No. 2 235-238
© 1986 by Society of Nuclear Medicine
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Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution

K. Hamacher, H. H. Coenen and G. Stöcklin

Institut für Chemie 1 (Nuklearchemie), Kernforschungsanlage Jülich GmbH, Jülich, FRG

Correspondence: For reprints contact: Kurt Hamacher, PhD, Institut für Chemie 1 (Nuklearchemie), Kernforschungsanlage Jülich GmgH, Postfach 1913, D-5170 Jülich, FRG.

ABSTRACT

An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced [18F]fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of ~ 50 min from EOB.




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D. C.P. Cobben, B. F.A.M. van der Laan, B. Maas, W. Vaalburg, A. J.H. Suurmeijer, H. J. Hoekstra, P. L. Jager, and P. H. Elsinga
18F-FLT PET for Visualization of Laryngeal Cancer: Comparison with 18F-FDG PET
J. Nucl. Med., February 1, 2004; 45(2): 226 - 231.
[Abstract] [Full Text] [PDF]

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D L Francis, A Freeman, D Visvikis, D C Costa, S K Luthra, M Novelli, I Taylor, and P J Ell
In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography
Gut, November 1, 2003; 52(11): 1602 - 1606.
[Abstract] [Full Text] [PDF]

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