Histologic Ex Vivo Validation of the [18F]SITATE Somatostatin Receptor PET Tracer

Nils F. Trautwein; Sven Mattern; Martina Hinterleitner; Gerald Reischl; Ralf Schirrmacher; Volker Steger; Silvio Nadalin; Konstantin Nikolaou; Johannes Schwenck; Stephan Singer; Christian la Fougère

doi:10.2967/jnumed.125.269619

Research ArticleClinical Investigation

Histologic Ex Vivo Validation of the [¹⁸F]SITATE Somatostatin Receptor PET Tracer

Nils F. Trautwein, Sven Mattern, Martina Hinterleitner, Gerald Reischl, Ralf Schirrmacher, Volker Steger, Silvio Nadalin, Konstantin Nikolaou, Johannes Schwenck, Stephan Singer and Christian la Fougère

Journal of Nuclear Medicine May 2025, jnumed.125.269619; DOI: https://doi.org/10.2967/jnumed.125.269619

Nils F. Trautwein

1Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tuebingen, Germany;

2ENETS Center of Excellence, University Hospital Tuebingen, Tuebingen, Germany;

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Sven Mattern

3Department of Pathology, University Hospital Tuebingen, Tuebingen, Germany;

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Martina Hinterleitner

2ENETS Center of Excellence, University Hospital Tuebingen, Tuebingen, Germany;

4Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, Tuebingen, Germany;

5DFG Cluster of Excellence 2180 “Image-Guided and Functional Instructed Tumor Therapy,” University of Tuebingen, Tuebingen, Germany;

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Gerald Reischl

5DFG Cluster of Excellence 2180 “Image-Guided and Functional Instructed Tumor Therapy,” University of Tuebingen, Tuebingen, Germany;

6Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University Tuebingen, Tuebingen, Germany;

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Ralf Schirrmacher

7Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, Alberta, Canada;

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Volker Steger

8Department of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, University Hospital Tuebingen, Tuebingen, Germany;

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Silvio Nadalin

2ENETS Center of Excellence, University Hospital Tuebingen, Tuebingen, Germany;

9Department of General, Visceral, and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany;

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Konstantin Nikolaou

5DFG Cluster of Excellence 2180 “Image-Guided and Functional Instructed Tumor Therapy,” University of Tuebingen, Tuebingen, Germany;

10Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany; and

11German Cancer Consortium, German Cancer Research Center, Partner Site Tuebingen, Tuebingen, Germany

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Johannes Schwenck

1Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tuebingen, Germany;

5DFG Cluster of Excellence 2180 “Image-Guided and Functional Instructed Tumor Therapy,” University of Tuebingen, Tuebingen, Germany;

6Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University Tuebingen, Tuebingen, Germany;

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Stephan Singer

2ENETS Center of Excellence, University Hospital Tuebingen, Tuebingen, Germany;

3Department of Pathology, University Hospital Tuebingen, Tuebingen, Germany;

5DFG Cluster of Excellence 2180 “Image-Guided and Functional Instructed Tumor Therapy,” University of Tuebingen, Tuebingen, Germany;

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Christian la Fougère

1Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tuebingen, Germany;

2ENETS Center of Excellence, University Hospital Tuebingen, Tuebingen, Germany;

5DFG Cluster of Excellence 2180 “Image-Guided and Functional Instructed Tumor Therapy,” University of Tuebingen, Tuebingen, Germany;

11German Cancer Consortium, German Cancer Research Center, Partner Site Tuebingen, Tuebingen, Germany

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Histologic Ex Vivo Validation of the [¹⁸F]SITATE Somatostatin Receptor PET Tracer

Nils F. Trautwein, Sven Mattern, Martina Hinterleitner, Gerald Reischl, Ralf Schirrmacher, Volker Steger, Silvio Nadalin, Konstantin Nikolaou, Johannes Schwenck, Stephan Singer, Christian la Fougère

Journal of Nuclear Medicine May 2025, jnumed.125.269619; DOI: 10.2967/jnumed.125.269619

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Histologic Ex Vivo Validation of the [¹⁸F]SITATE Somatostatin Receptor PET Tracer

Nils F. Trautwein, Sven Mattern, Martina Hinterleitner, Gerald Reischl, Ralf Schirrmacher, Volker Steger, Silvio Nadalin, Konstantin Nikolaou, Johannes Schwenck, Stephan Singer, Christian la Fougère

Journal of Nuclear Medicine May 2025, jnumed.125.269619; DOI: 10.2967/jnumed.125.269619

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Keywords

oncology
PET
radiotracer tissue kinetics
neuroendocrine neoplasms
SSTR PET
[18F]SITATE

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