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Research ArticleThe State of the Art

Rethinking Dosimetry: A European Perspective

Johannes Tran-Gia, Francesco Cicone, Michel Koole, Francesco Giammarile, Jonathan Gear, Emmanuel Deshayes, Pablo Minguez Gabiña, Marta Cremonesi, Jonathan Wadsley, Peter Bernhardt, Manuel Bardiès, Silvano Gnesin, Mattias Sandström, Ulrike Garske-Román, Mona-Elisabeth R. Revheim, Frederik A. Verburg, Mark Konijnenberg, Bernd Joachim Krause, Michael Lassmann and Caroline Stokke
Journal of Nuclear Medicine May 2025, jnumed.124.269378; DOI: https://doi.org/10.2967/jnumed.124.269378
Johannes Tran-Gia
1Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany;
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Francesco Cicone
2Nuclear Medicine Unit, Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Catanzaro, Italy;
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Michel Koole
3Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium;
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Francesco Giammarile
4Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria;
5Service de Médecine Nucléaire, Centre Léon Bérard, Lyon, France;
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Jonathan Gear
6Joint Department of Physics, Royal Marsden NHSFT and Institute of Cancer Research, Sutton, United Kingdom;
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Emmanuel Deshayes
7Département de Médecine Nucléaire, Institut Régional du Cancer de Montpellier, Montpellier University, Montpellier, France;
8Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Équipe Labellisée Ligue Contre le Cancer, Institut Régional du Cancer de Montpellier, Université de Montpellier, Montpellier, France;
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Pablo Minguez Gabiña
9Department of Medical Physics and Radiation Protection, Gurutzeta-Cruces University Hospital/Biocruces Health Research Institute, Barakaldo, Spain;
10Department of Applied Physics, Faculty of Engineering, UPV/EHU, Bilbao, Spain;
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Marta Cremonesi
11Department of Medical Imaging and Radiation Sciences, European Institute of Oncology, IRCCS, Milan, Italy;
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Jonathan Wadsley
12Weston Park Hospital, Sheffield, United Kingdom;
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Peter Bernhardt
13Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; and Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden;
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Manuel Bardiès
7Département de Médecine Nucléaire, Institut Régional du Cancer de Montpellier, Montpellier University, Montpellier, France;
8Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Équipe Labellisée Ligue Contre le Cancer, Institut Régional du Cancer de Montpellier, Université de Montpellier, Montpellier, France;
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Silvano Gnesin
14Institute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland;
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Mattias Sandström
15Department of Radiology, Uppsala University, Uppsala, Sweden;
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Ulrike Garske-Román
16Department of Oncology, Uppsala University Hospital, Uppsala, Sweden;
17Department of Nuclear Medicine, Uppsala University Hospital, Uppsala, Sweden;
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Mona-Elisabeth R. Revheim
18Intervention Centre, Oslo University Hospital, Oslo, Norway;
19Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;
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Frederik A. Verburg
20Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands;
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Mark Konijnenberg
20Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands;
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Bernd Joachim Krause
21Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Michael Lassmann
1Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany;
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Caroline Stokke
22Division of Radiology and Nuclear Medicine, Department of Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway; and
23Department of Physics, University of Oslo, Oslo, Norway
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Rethinking Dosimetry: A European Perspective
Johannes Tran-Gia, Francesco Cicone, Michel Koole, Francesco Giammarile, Jonathan Gear, Emmanuel Deshayes, Pablo Minguez Gabiña, Marta Cremonesi, Jonathan Wadsley, Peter Bernhardt, Manuel Bardiès, Silvano Gnesin, Mattias Sandström, Ulrike Garske-Román, Mona-Elisabeth R. Revheim, Frederik A. Verburg, Mark Konijnenberg, Bernd Joachim Krause, Michael Lassmann, Caroline Stokke
Journal of Nuclear Medicine May 2025, jnumed.124.269378; DOI: 10.2967/jnumed.124.269378

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Rethinking Dosimetry: A European Perspective
Johannes Tran-Gia, Francesco Cicone, Michel Koole, Francesco Giammarile, Jonathan Gear, Emmanuel Deshayes, Pablo Minguez Gabiña, Marta Cremonesi, Jonathan Wadsley, Peter Bernhardt, Manuel Bardiès, Silvano Gnesin, Mattias Sandström, Ulrike Garske-Román, Mona-Elisabeth R. Revheim, Frederik A. Verburg, Mark Konijnenberg, Bernd Joachim Krause, Michael Lassmann, Caroline Stokke
Journal of Nuclear Medicine May 2025, jnumed.124.269378; DOI: 10.2967/jnumed.124.269378
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  • Article
    • Abstract
    • TREATMENT PLANNING VERSUS ABSORBED DOSE VERIFICATION
    • WHY EBRT DOSIMETRY MODELS ARE INADEQUATE FOR RPT
    • DEVELOPING ADERS IN RPT
    • RADIOTOXICITY AND ABSORBED DOSE CONSTRAINTS IN RPT
    • THE NEED FOR WELL-DESIGNED TRIALS IN EVALUATING RPT DOSIMETRY
    • SHAPING THE FUTURE: LEGAL AND PRACTICAL STEPS FOR RPT DOSIMETRY
    • DISCLOSURE
    • ACKNOWLEDGMENTS
    • Footnotes
    • REFERENCES
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Keywords

  • absorbed dose
  • dosimetry
  • molecular radiotherapy
  • MRT
  • radionuclide therapy
  • radiopharmaceutical therapy
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