Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis

Randy Yeh; Fresia Pareja; Parnian Shobeiri; Dara Ross; Vetri S. Jayaprakasam; Ali Aria Razmaria; Joshua Z. Drago; Audrey Mauguen; Serge K. Lyashchenko; Brian M. Zeglis; Jason S. Lewis; Gary A. Ulaner

doi:10.2967/jnumed.124.269227

Research ArticleClinical Investigation

Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis

Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S. Jayaprakasam, Ali Aria Razmaria, Joshua Z. Drago, Audrey Mauguen, Serge K. Lyashchenko, Brian M. Zeglis, Jason S. Lewis and Gary A. Ulaner

Journal of Nuclear Medicine May 2025, jnumed.124.269227; DOI: https://doi.org/10.2967/jnumed.124.269227

Randy Yeh

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

2Department of Radiology, Weill Cornell Medical College, New York, New York;

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Fresia Pareja

3Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;

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Parnian Shobeiri

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Dara Ross

3Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;

4Department of Pathology, Weill Cornell Medical College, New York, New York;

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Vetri S. Jayaprakasam

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

2Department of Radiology, Weill Cornell Medical College, New York, New York;

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Ali Aria Razmaria

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

2Department of Radiology, Weill Cornell Medical College, New York, New York;

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Joshua Z. Drago

5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;

6Department of Medicine, Weill Cornell Medical College, New York, New York;

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Audrey Mauguen

7Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Serge K. Lyashchenko

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

2Department of Radiology, Weill Cornell Medical College, New York, New York;

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Brian M. Zeglis

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

2Department of Radiology, Weill Cornell Medical College, New York, New York;

8Department of Chemistry, Hunter College, New York, New York;

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Jason S. Lewis

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

2Department of Radiology, Weill Cornell Medical College, New York, New York;

9Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Gary A. Ulaner

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

10Molecular Imaging and Therapy, Hoag Family Cancer Institute, Newport Beach, California; and

11Departments of Radiology and Translational Genomics, University of Southern California, Los Angeles, California

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis

Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S. Jayaprakasam, Ali Aria Razmaria, Joshua Z. Drago, Audrey Mauguen, Serge K. Lyashchenko, Brian M. Zeglis, Jason S. Lewis, Gary A. Ulaner

Journal of Nuclear Medicine May 2025, jnumed.124.269227; DOI: 10.2967/jnumed.124.269227

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Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis

Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S. Jayaprakasam, Ali Aria Razmaria, Joshua Z. Drago, Audrey Mauguen, Serge K. Lyashchenko, Brian M. Zeglis, Jason S. Lewis, Gary A. Ulaner

Journal of Nuclear Medicine May 2025, jnumed.124.269227; DOI: 10.2967/jnumed.124.269227

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Keywords

HER2
PET
breast cancer
pathology

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Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis

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