Research ArticleBasic Science Investigation
Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives 68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics
Hongzhang Yang, Jiarou Wang, Xuejun Wen, Huifeng Guo, Vivianne Jakobsson, Tianzhi Zhao, Fantian Zeng, Huaxiang Shen, Heng Zhang, Xiaomin Liu, Yatong Qin, Xinyi Li, Hehe Xiong, Zijian Zhou, Jingjing Zhang and Xiaoyuan Chen
Journal of Nuclear Medicine March 2025, jnumed.124.268959; DOI: https://doi.org/10.2967/jnumed.124.268959
Hongzhang Yang
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;
3Theranostics Center of Excellenece, Yong Loo Lin School of Medicine, National University of Singapore, Helios, Singapore;
4Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
Jiarou Wang
5Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
Xuejun Wen
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;
3Theranostics Center of Excellenece, Yong Loo Lin School of Medicine, National University of Singapore, Helios, Singapore;
4Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
Huifeng Guo
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Vivianne Jakobsson
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;
3Theranostics Center of Excellenece, Yong Loo Lin School of Medicine, National University of Singapore, Helios, Singapore;
4Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
6Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
Tianzhi Zhao
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;
3Theranostics Center of Excellenece, Yong Loo Lin School of Medicine, National University of Singapore, Helios, Singapore;
4Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
6Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
Fantian Zeng
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Huaxiang Shen
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Heng Zhang
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Xiaomin Liu
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Yatong Qin
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Xinyi Li
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Hehe Xiong
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Zijian Zhou
1State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’an Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China;
Jingjing Zhang
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;
3Theranostics Center of Excellenece, Yong Loo Lin School of Medicine, National University of Singapore, Helios, Singapore;
4Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
6Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
Xiaoyuan Chen
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;
3Theranostics Center of Excellenece, Yong Loo Lin School of Medicine, National University of Singapore, Helios, Singapore;
4Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
6Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
7Department of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore;
8Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore;
9Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore; and
10Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Proteos, Singapore

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In this issue
Journal of Nuclear Medicine
Vol. 66, Issue 4
April 1, 2025
Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives 68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics
Hongzhang Yang, Jiarou Wang, Xuejun Wen, Huifeng Guo, Vivianne Jakobsson, Tianzhi Zhao, Fantian Zeng, Huaxiang Shen, Heng Zhang, Xiaomin Liu, Yatong Qin, Xinyi Li, Hehe Xiong, Zijian Zhou, Jingjing Zhang, Xiaoyuan Chen
Journal of Nuclear Medicine Mar 2025, jnumed.124.268959; DOI: 10.2967/jnumed.124.268959
Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives 68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics
Hongzhang Yang, Jiarou Wang, Xuejun Wen, Huifeng Guo, Vivianne Jakobsson, Tianzhi Zhao, Fantian Zeng, Huaxiang Shen, Heng Zhang, Xiaomin Liu, Yatong Qin, Xinyi Li, Hehe Xiong, Zijian Zhou, Jingjing Zhang, Xiaoyuan Chen
Journal of Nuclear Medicine Mar 2025, jnumed.124.268959; DOI: 10.2967/jnumed.124.268959
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