Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [68Ga]Ga-PSMA-11 PET/CT in the proPSMA Study

David C. Chen; James P. Buteau; Louise Emmett; Ramin Alipour; Felipe de Galiza Barbosa; Matthew J. Roberts; Aoife McVey; Jonathan O’Brien; Sidney Levy; Roslyn J. Francis; Nathan Lawrentschuk; Declan G. Murphy; Michael S. Hofman

doi:10.2967/jnumed.124.268901

Research ArticleClinical Investigation

Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [⁶⁸Ga]Ga-PSMA-11 PET/CT in the proPSMA Study

David C. Chen, James P. Buteau, Louise Emmett, Ramin Alipour, Felipe de Galiza Barbosa, Matthew J. Roberts, Aoife McVey, Jonathan O’Brien, Sidney Levy, Roslyn J. Francis, Nathan Lawrentschuk, Declan G. Murphy and Michael S. Hofman

Journal of Nuclear Medicine March 2025, jnumed.124.268901; DOI: https://doi.org/10.2967/jnumed.124.268901

David C. Chen

1Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

2Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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James P. Buteau

1Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Louise Emmett

4Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

5Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

6St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia;

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Ramin Alipour

1Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Felipe de Galiza Barbosa

7Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland;

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Matthew J. Roberts

8Department of Urology, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia;

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Aoife McVey

9Department of Radiology, University Hospital Geelong, Geelong, Victoria, Australia;

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Jonathan O’Brien

2Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Sidney Levy

1Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Roslyn J. Francis

10Department of Nuclear Medicine, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia;

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Nathan Lawrentschuk

2Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

11Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia; and

12EJ Whitten Foundation Prostate Cancer Research Centre at Epworth, Richmond, Victoria, Australia

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Declan G. Murphy

2Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Michael S. Hofman

1Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [⁶⁸Ga]Ga-PSMA-11 PET/CT in the proPSMA Study

Journal of Nuclear Medicine Mar 2025, jnumed.124.268901; DOI: 10.2967/jnumed.124.268901

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Journal of Nuclear Medicine Mar 2025, jnumed.124.268901; DOI: 10.2967/jnumed.124.268901

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Keywords

prostate cancer
prostate-specific membrane antigen
PET/CT

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Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [⁶⁸Ga]Ga-PSMA-11 PET/CT in the proPSMA Study

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