Measuring Total Metabolic Tumor Volume from 18F-FDG PET: A Reality Check

Ronald Boellaard; Gerben J.C. Zwezerijnen; Irène Buvat; Laurence Champion; Narinée Hovhannisyan-Baghdasarian; Fanny Orlhac; Anne I.J. Arens; Daphne Lobeek; Filiz Celik; Cristina Mitea; Julia E. Huijbregts; Nelleke Tolboom; Bart de Keizer; Roelf Valkema; Floris H.P. van Velden; Petra Dibbets-Schneider; Sanne E. Wiegers; Pieternella J. Lugtenburg; Sally F. Barrington; Josée M. Zijlstra

doi:10.2967/jnumed.124.269271

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Measuring Total Metabolic Tumor Volume from ¹⁸F-FDG PET: A Reality Check

Ronald Boellaard, Gerben J.C. Zwezerijnen, Irène Buvat, Laurence Champion, Narinée Hovhannisyan-Baghdasarian, Fanny Orlhac, Anne I.J. Arens, Daphne Lobeek, Filiz Celik, Cristina Mitea, Julia E. Huijbregts, Nelleke Tolboom, Bart de Keizer, Roelf Valkema, Floris H.P. van Velden, Petra Dibbets-Schneider, Sanne E. Wiegers, Pieternella J. Lugtenburg, Sally F. Barrington and Josée M. Zijlstra

Journal of Nuclear Medicine May 2025, 66 (5) 802-805; DOI: https://doi.org/10.2967/jnumed.124.269271

Ronald Boellaard

1Department of Radiology and Nuclear Medicine, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands;

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Gerben J.C. Zwezerijnen

1Department of Radiology and Nuclear Medicine, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands;

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Irène Buvat

2LITO, Inserm, Institut Curie, Orsay, France;

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Laurence Champion

2LITO, Inserm, Institut Curie, Orsay, France;

3Department of Nuclear Medicine, Institut Curie, Saint-Cloud, France;

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Narinée Hovhannisyan-Baghdasarian

2LITO, Inserm, Institut Curie, Orsay, France;

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Fanny Orlhac

2LITO, Inserm, Institut Curie, Orsay, France;

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Anne I.J. Arens

4Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands;

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Daphne Lobeek

5Department of Radiology and Nuclear Medicine, Catharina Hospital, Eindhoven, The Netherlands;

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Filiz Celik

6Center for Radiology and Nuclear Medicine, Department of Nuclear Medicine, Deventer Hospital, Deventer, The Netherlands;

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Cristina Mitea

7Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, and GROW - Research Institute for Oncology and Reproduction, Maastricht, The Netherlands;

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Julia E. Huijbregts

8Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands;

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Nelleke Tolboom

9Department of Nuclear Medicine and Radiology, UMC Utrecht, Utrecht, The Netherlands;

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Bart de Keizer

9Department of Nuclear Medicine and Radiology, UMC Utrecht, Utrecht, The Netherlands;

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Roelf Valkema

10Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands;

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Floris H.P. van Velden

11Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands;

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Petra Dibbets-Schneider

11Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands;

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Sanne E. Wiegers

1Department of Radiology and Nuclear Medicine, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands;

12Department of Hematology, Amsterdam UMC, Cancer Center Amsterdam, and HOVON Imaging working group, Amsterdam, The Netherlands;

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Pieternella J. Lugtenburg

13Department of Hematology, Erasmus MC, Rotterdam, The Netherlands; and

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Sally F. Barrington

14King’s College London and Guy’s and St. Thomas’s PET Centre, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom

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Josée M. Zijlstra

12Department of Hematology, Amsterdam UMC, Cancer Center Amsterdam, and HOVON Imaging working group, Amsterdam, The Netherlands;

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May 1, 2025

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Measuring Total Metabolic Tumor Volume from ¹⁸F-FDG PET: A Reality Check

Journal of Nuclear Medicine May 2025, 66 (5) 802-805; DOI: 10.2967/jnumed.124.269271

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Measuring Total Metabolic Tumor Volume from ¹⁸F-FDG PET: A Reality Check

Journal of Nuclear Medicine May 2025, 66 (5) 802-805; DOI: 10.2967/jnumed.124.269271

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