Biodistribution, Safety Profile, and Radiation Dosimetry of [18F]SYN2, a PET Cardiac Perfusion Tracer, in Healthy Subjects

Juhani Knuuti; Małgorzata Kobylecka; Seweryn Krajewski; Lukasz Steczek; Karina Gotowicz; Joanna Towpik; Kari Kalliokoski; Tuula Tolvanen; Magdalena Kostkiewicz; Przemysław Kozanecki; Joanna Włostowska; Mirosław Dziuk; Leszek Królicki; Jacek Bil; Piotr J. Slomka; Timothy M. Bateman; Mouaz H. Al-Mallah; Panithaya Chareonthaitawee; Prem Soman; Cezary Kozanecki

doi:10.2967/jnumed.124.268872

Research ArticleClinical Investigation

Biodistribution, Safety Profile, and Radiation Dosimetry of [¹⁸F]SYN2, a PET Cardiac Perfusion Tracer, in Healthy Subjects

Juhani Knuuti, Małgorzata Kobylecka, Seweryn Krajewski, Lukasz Steczek, Karina Gotowicz, Joanna Towpik, Kari Kalliokoski, Tuula Tolvanen, Magdalena Kostkiewicz, Przemysław Kozanecki, Joanna Włostowska, Mirosław Dziuk, Leszek Królicki, Jacek Bil, Piotr J. Slomka, Timothy M. Bateman, Mouaz H. Al-Mallah, Panithaya Chareonthaitawee, Prem Soman and Cezary Kozanecki

Journal of Nuclear Medicine April 2025, 66 (4) 626-633; DOI: https://doi.org/10.2967/jnumed.124.268872

Juhani Knuuti

1Turku PET Centre and Faculty of Medicine, Turku University Hospital and University of Turku, Turku, Finland;

2Department of Clinical Physiology, Nuclear Medicine, and PET, Turku University Hospital, Turku, Finland;

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Małgorzata Kobylecka

3Department of Nuclear Medicine, Medical University of Warsaw, Warsaw, Poland;

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Seweryn Krajewski

4Research and Development Centre, Synektik SA, Warsaw, Poland;

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Lukasz Steczek

4Research and Development Centre, Synektik SA, Warsaw, Poland;

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Karina Gotowicz

4Research and Development Centre, Synektik SA, Warsaw, Poland;

5Department of Chemistry, University of Warsaw, Warsaw, Poland;

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Joanna Towpik

4Research and Development Centre, Synektik SA, Warsaw, Poland;

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Kari Kalliokoski

1Turku PET Centre and Faculty of Medicine, Turku University Hospital and University of Turku, Turku, Finland;

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Tuula Tolvanen

1Turku PET Centre and Faculty of Medicine, Turku University Hospital and University of Turku, Turku, Finland;

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Magdalena Kostkiewicz

6Department of Cardiovascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland;

7Department of Nuclear Medicine, Hospital John Paul II, Krakow, Poland;

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Przemysław Kozanecki

4Research and Development Centre, Synektik SA, Warsaw, Poland;

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Joanna Włostowska

4Research and Development Centre, Synektik SA, Warsaw, Poland;

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Mirosław Dziuk

8Nuclear Medicine Department, Military Institute of Medicine–National Research Institute, Warsaw, Poland;

9Affidea Poland, Warsaw, Poland;

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Leszek Królicki

3Department of Nuclear Medicine, Medical University of Warsaw, Warsaw, Poland;

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Jacek Bil

10National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland;

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Piotr J. Slomka

11Departments of Medicine and Cardiology, Cedars Sinai Medical Center, Los Angeles, California;

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Timothy M. Bateman

12Mid America Heart Institute and the Saint Luke’s Health System, Kansas City, Missouri;

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Mouaz H. Al-Mallah

13Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas;

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Panithaya Chareonthaitawee

14Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; and

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Prem Soman

15Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

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Cezary Kozanecki

4Research and Development Centre, Synektik SA, Warsaw, Poland;

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Journal of Nuclear Medicine

Vol. 66, Issue 4

April 1, 2025

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Biodistribution, Safety Profile, and Radiation Dosimetry of [¹⁸F]SYN2, a PET Cardiac Perfusion Tracer, in Healthy Subjects

Journal of Nuclear Medicine Apr 2025, 66 (4) 626-633; DOI: 10.2967/jnumed.124.268872

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Biodistribution, Safety Profile, and Radiation Dosimetry of [¹⁸F]SYN2, a PET Cardiac Perfusion Tracer, in Healthy Subjects

Journal of Nuclear Medicine Apr 2025, 66 (4) 626-633; DOI: 10.2967/jnumed.124.268872

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Keywords

[18F]tracer
phase I clinical study
MPI
cardiac imaging
PET imaging
[18F]SYN2

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