A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[18F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism

Daniel Gillett; Russell Senanayake; James MacFarlane; Waiel Bashari; August Palma; Lihua Hu; Ines Harper; Iosif A. Mendichovszky; Gunnar Antoni; Per Hellman; Anders Sundin; Matthew Hird; István Boros; Morris J. Brown; Heok Cheow; Luigi Aloj; Franklin Aigbirhio; Mark Gurnell

doi:10.2967/jnumed.124.268425

Research ArticleClinical Investigation

A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[¹⁸F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism

Daniel Gillett, Russell Senanayake, James MacFarlane, Waiel Bashari, August Palma, Lihua Hu, Ines Harper, Iosif A. Mendichovszky, Gunnar Antoni, Per Hellman, Anders Sundin, Matthew Hird, István Boros, Morris J. Brown, Heok Cheow, Luigi Aloj, Franklin Aigbirhio and Mark Gurnell

Journal of Nuclear Medicine March 2025, 66 (3) 434-440; DOI: https://doi.org/10.2967/jnumed.124.268425

Daniel Gillett

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;

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Russell Senanayake

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

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James MacFarlane

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

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Waiel Bashari

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

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August Palma

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

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Lihua Hu

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

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Ines Harper

2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;

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Iosif A. Mendichovszky

2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;

3Department of Radiology, University of Cambridge, Cambridge, United Kingdom;

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Gunnar Antoni

4Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

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Per Hellman

5Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;

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Anders Sundin

5Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;

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Matthew Hird

6Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom;

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István Boros

7Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; and

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Morris J. Brown

8Department of Endocrinology, Queen Mary University of London, London, United Kingdom

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Heok Cheow

2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;

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Luigi Aloj

2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;

3Department of Radiology, University of Cambridge, Cambridge, United Kingdom;

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Franklin Aigbirhio

6Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom;

7Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; and

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Mark Gurnell

1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;

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Journal of Nuclear Medicine

Vol. 66, Issue 3

March 1, 2025

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A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[¹⁸F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism

Journal of Nuclear Medicine Mar 2025, 66 (3) 434-440; DOI: 10.2967/jnumed.124.268425

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A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[¹⁸F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism

Journal of Nuclear Medicine Mar 2025, 66 (3) 434-440; DOI: 10.2967/jnumed.124.268425

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Keywords

primary aldosteronism
PET
Molecular imaging
[18F]CETO

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A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[¹⁸F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism

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