Initial Experience with [177Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction

Andrei Gafita; Andrew Voter; Somya Shesadri; Avery Spitz; Catherine H. Marshall; Steven P. Rowe; Mark C. Markowski; Martin G. Pomper; A. Cahid Civelek; Michael A. Carducci; Samuel R. Denmeade; Jeffrey Young; Kenneth J. Pienta; Channing J. Paller; Lilja B. Solnes

doi:10.2967/jnumed.124.267723

Research ArticleClinical Investigation

Initial Experience with [¹⁷⁷Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction

Andrei Gafita, Andrew Voter, Somya Shesadri, Avery Spitz, Catherine H. Marshall, Steven P. Rowe, Mark C. Markowski, Martin G. Pomper, A. Cahid Civelek, Michael A. Carducci, Samuel R. Denmeade, Jeffrey Young, Kenneth J. Pienta, Channing J. Paller and Lilja B. Solnes

Journal of Nuclear Medicine November 2024, 65 (11) 1724-1730; DOI: https://doi.org/10.2967/jnumed.124.267723

Andrei Gafita

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

2Johns Hopkins Theranostics Center, Baltimore, Maryland;

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Andrew Voter

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

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Somya Shesadri

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

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Avery Spitz

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

2Johns Hopkins Theranostics Center, Baltimore, Maryland;

3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland; and

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Catherine H. Marshall

3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland; and

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Steven P. Rowe

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

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Mark C. Markowski

3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland; and

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Martin G. Pomper

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

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A. Cahid Civelek

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

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Michael A. Carducci

3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland; and

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Samuel R. Denmeade

3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland; and

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Jeffrey Young

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

2Johns Hopkins Theranostics Center, Baltimore, Maryland;

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Kenneth J. Pienta

4Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, Maryland

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Channing J. Paller

3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland; and

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Lilja B. Solnes

1Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland;

2Johns Hopkins Theranostics Center, Baltimore, Maryland;

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Vol. 65, Issue 11

November 1, 2024

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Initial Experience with [¹⁷⁷Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction

Journal of Nuclear Medicine Nov 2024, 65 (11) 1724-1730; DOI: 10.2967/jnumed.124.267723

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Initial Experience with [¹⁷⁷Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction

Journal of Nuclear Medicine Nov 2024, 65 (11) 1724-1730; DOI: 10.2967/jnumed.124.267723

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Keywords

metastatic castration-resistant prostate cancer
PSMA PET
ctDNA
SelectPSMA
LuPSMA
radiopharmaceutical therapy

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Initial Experience with [¹⁷⁷Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction

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