Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleEditor's Page

To Scan or Not to Scan: An Unnecessary Dilemma for PSMA Radioligand Therapy

Sandy Srinivas and Andrei Iagaru
Journal of Nuclear Medicine November 2021, 62 (11) 1487-1488; DOI: https://doi.org/10.2967/jnumed.121.263035
Sandy Srinivas
1Division of Medical Oncology, Department of Medicine, Stanford University, Stanford, California; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrei Iagaru
2Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

The recently presented and published results of the VISION phase III study of 177Lu-PSMA617 for metastatic castration-resistant prostate cancer (1) are indeed one of the greatest success stories in the history of nuclear medicine (2). They add to the earlier experiences from first-in-humans studies (3–5) to phase II studies (6). However, danger lurks in this wave of unprecedented progress. The fact that more than 85% of screened participants met the 68Ga-PSMA11 eligibility criteria (1) made some question the need for prostate-specific membrane antigen (PSMA) PET imaging before 177Lu-PSMA treatment. This questioning of the need for PSMA PET is done without re-evaluating the eligibility criteria themselves (not all lesions had to be PSMA-positive) and their impact on study outcomes. Some will be ready to make the argument that excluding PSMA PET will eliminate costs and increase access to therapy. Let us next clearly make the case against this approach.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Andrei Iagaru, MD

One of the undisputed principles of treating patients with cancer is knowing the extent of disease to the best of one’s ability. Physicians practicing medical or radiation oncology who do not accurately define where cancer is and where it is not before using chemotherapy or external radiation would be viewed as derelict in their duties. So why would radioligand therapy for prostate cancer be treated any differently?

177Lu-PSMA617 is not expected have a low cost, nor is it without adverse events. Therefore, proper patient selection based on targeted PSMA PET imaging is necessary. By excluding patients unlikely to respond, PSMA PET will likely save health-care costs in the long run. It will also contribute prognostic factors for prediction of response to treatment (7), as well as reduce the possibility of adverse events by excluding ineligible patients. In fact, more PSMA PET imaging is likely needed during radioligand therapy, such as for evaluation of response to therapy mid-treatment and after the last cycle, replacing standard assessments with CT and bone scintigraphy.

The biology of prostate cancer is complex, and a single imaging test, no matter how good, may not be sufficient to properly select patients. The TheraP phase II study required baseline 68Ga-PSMA11 PET, as well as 18F-FDG PET to exclude patients with active disease sites lacking PSMA expression (6). The outcomes, not surprisingly, appear superior to those reported in VISION and serve as a further argument for accurate eligibility screening.

Access to PSMA PET in the United States was a considerable issue before the Food and Drug Administration approval of 2 radiopharmaceuticals (68Ga-PSMA11 and 18F-DCFPyL). With industry backing and logistics being addressed, the big limiting factor will be inaccurate claims that imaging is not needed before treatment.

We have been through similar debates for the treatment of differentiated thyroid cancer (8). Some physicians still chose not to conduct a whole-body scan with a diagnostic activity of either 131I or 123I. Others, including our group, always obtain this information. There are several reasons for this divergence of opinion. First, most patients with differentiated thyroid cancer have a very good prognosis. This is not the case with prostate cancer. Physicians often equate the excellent outcome with how they manage the cancer rather than with the natural history of the disease. They argue that if the patients have a good outcome without a whole-body scan then the scan is not necessary. Second, obtaining a posttherapy scan provides information regarding staging. But since when is it appropriate to stage disease after treating the patient? Third, stunning was debated and put to rest (9). There is no need to go through the same for radioligand therapy in prostate cancer.

European Association of Nuclear Medicine procedure guidelines for radionuclide therapy with 177Lu-labeled PSMA ligands properly include PSMA PET imaging for patient selection (10). These guidelines should be reviewed regularly and revised as needed to include emerging data demonstrating the benefits of PSMA PET imaging. Additional professional organizations should endorse them and make them a part of appropriate-use criteria.

The additional resources and cost to obtain the useful information from PSMA PET are a small fraction of what a prostate cancer patient and the health-care system will spend from the discovery of an elevated prostate-specific antigen level through referral to specialists, biopsy, surgery, radiation therapy, chemotherapy, hormonal therapy, radioligand therapy, and the long-term follow-up of the cancer.

We are in the era of precision medicine and precision health (11), aiming to individualize therapies to achieve maximum benefit, including in prostate cancer. As an example, patients are getting genomic testing for BRCA mutations and would get a poly(adenosine diphosphate-ribose polymerase) inhibitor only if tested positive (12). Giving a patient such an inhibitor without testing is not accepted. We hope the prostate cancer medical community will stand up for precision medicine, including by ordering PSMA (and 18F-FDG) PET before treating a patient with 177Lu-PSMA617. PSMA radioligand therapy for prostate cancer without PSMA PET should not be accepted.

DISCLOSURE

No potential conflict of interest relevant to this article was reported.

Footnotes

  • Published online August 26, 2021.

  • © 2021 by the Society of Nuclear Medicine and Molecular Imaging.

REFERENCES

  1. 1.↵
    1. Sartor O,
    2. de Bono J,
    3. Chi KN,
    4. et al
    . Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer. N Engl J Med. 2021;385:1091–1103.
    OpenUrlCrossRef
  2. 2.↵
    1. Czernin J,
    2. Calais J.
    177Lu-PSMA617 and the VISION trial: one of the greatest success stories in the history of nuclear medicine. J Nucl Med. 2021;62:1025–1026.
    OpenUrlFREE Full Text
  3. 3.↵
    1. Delker A,
    2. Fendler WP,
    3. Kratochwil C,
    4. et al
    . Dosimetry for 177Lu-DKFZ-PSMA-617: a new radiopharmaceutical for the treatment of metastatic prostate cancer. Eur J Nucl Med Mol Imaging. 2016;43:42–51.
    OpenUrlCrossRefPubMed
  4. 4.
    1. Kratochwil C,
    2. Giesel FL,
    3. Stefanova M,
    4. et al
    . PSMA-targeted radionuclide therapy of metastatic castration-resistant prostate cancer with 177Lu-labeled PSMA-617. J Nucl Med. 2016;57:1170–1176.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Rahbar K,
    2. Ahmadzadehfar H,
    3. Kratochwil C,
    4. et al
    . German multicenter study investigating 177Lu-PSMA-617 radioligand therapy in advanced prostate cancer patients. J Nucl Med. 2017;58:85–90.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Hofman MS,
    2. Emmett L,
    3. Sandhu S,
    4. et al
    . [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial. Lancet. 2021;397:797–804.
    OpenUrl
  7. 7.↵
    1. Seifert R,
    2. Kessel K,
    3. Schlack K,
    4. et al
    . PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [177Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis. Eur J Nucl Med Mol Imaging. 2021;48:1200–1210.
    OpenUrl
  8. 8.↵
    1. McDougall IR.
    The case for obtaining a diagnostic whole-body scan prior to iodine 131 treatment of differentiated thyroid cancer. Thyroid. 2009;19:811–813.
    OpenUrlPubMed
  9. 9.↵
    1. McDougall IR,
    2. Iagaru A.
    Thyroid stunning: fact or fiction? Semin Nucl Med. 2011;41:105–112.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Kratochwil C,
    2. Fendler WP,
    3. Eiber M,
    4. et al
    . EANM procedure guidelines for radionuclide therapy with 177Lu-labelled PSMA-ligands (177Lu-PSMA-RLT). Eur J Nucl Med Mol Imaging. 2019;46:2536–2544.
    OpenUrl
  11. 11.↵
    1. Gambhir SS,
    2. Ge TJ,
    3. Vermesh O,
    4. Spitler R.
    Toward achieving precision health. Sci Transl Med. 2018;10:eaao3612.
    OpenUrlFREE Full Text
  12. 12.↵
    1. Anscher MS,
    2. Chang E,
    3. Gao X,
    4. et al
    . FDA approval summary: rucaparib for the treatment of patients with deleterious BRCA-mutated metastatic castrate-resistant prostate cancer. Oncologist. 2021;26:139–146.
    OpenUrl
  • Received for publication August 10, 2021.
  • Accepted for publication August 11, 2021.
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 62 (11)
Journal of Nuclear Medicine
Vol. 62, Issue 11
November 1, 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
To Scan or Not to Scan: An Unnecessary Dilemma for PSMA Radioligand Therapy
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
To Scan or Not to Scan: An Unnecessary Dilemma for PSMA Radioligand Therapy
Sandy Srinivas, Andrei Iagaru
Journal of Nuclear Medicine Nov 2021, 62 (11) 1487-1488; DOI: 10.2967/jnumed.121.263035

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
To Scan or Not to Scan: An Unnecessary Dilemma for PSMA Radioligand Therapy
Sandy Srinivas, Andrei Iagaru
Journal of Nuclear Medicine Nov 2021, 62 (11) 1487-1488; DOI: 10.2967/jnumed.121.263035
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Is 18F-FDG PET Needed to Assess 177Lu-PSMA Therapy Eligibility? A VISION-like, Single-Center Analysis
  • Clinical Trials of Prostate-Specific Membrane Antigen Radiopharmaceutical Therapy
  • 177Lu-PSMA Therapy
  • Why We Did What We Did: PSMA PET/CT Selection Criteria for the VISION Trial
  • The VISION Forward: Recognition and Implication of PSMA-/18F-FDG+ mCRPC
  • A VISION of ALSYMPCA
  • Google Scholar

More in this TOC Section

  • What Is Theranostics?
  • How Many Theranostics Centers Will We Need in the United States?
  • PSMA Expression Assessed by PET Imaging Is a Required Biomarker for Selecting Patients for Any PSMA-Targeted Therapy
Show more Editor's Page

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire