JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
Journal of Nuclear Medicine Vol. 50 No. 8 11A-12A
© 2009 by Society of Nuclear Medicine

This Month in JNM

Tyrosine kinase epidermal cancer imaging: Mishani and Hagooly focus on strategies for molecular imaging and quantification of epidermal growth factor receptor–tyrosine kinase in cancer and outline the potential for these techniques in clinical practice.
Page 1199
Figure 1

Significance of kinetic enhancement: Berridge provides perspective on the role of kinetic enhancement in radiopharmaceutical effectiveness and previews an article in this issue of JNM on the effect of radiopharmaceutical-to-serum protein binding on tracer kinetics.
Page 1203

Preoperative PET in head and neck cancer: Rodrigues and colleagues compare optimized whole-body and dedicated high-resolution contrast-enhanced PET/CT protocols and contrast-enhanced CT in preoperative staging of primary squamous cell carcinoma of the head and neck.
Page 1205
Figure 2

PET detection of bone metastases: Putzer and colleagues assess the comparative diagnostic values of CT imaging and somatostatin analog 68Ga-DOTATOC PET in early detection of bone metastases from neuroendocrine tumors.
Page 1214
Figure 3

11C-acetate uptake regulation in HCC: Yun and colleagues explore patterns of 11C-acetate and 18F-FDG uptake on PET/CT and expression of regulatory enzymes related to glycolysis and lipid synthesis in hepatocellular carcinoma.
Page 1222

Receptor mapping with Hypotime: Møller and colleagues describe a method of calculation that uses 11C-WAY washout rather than accumulation on PET to map serotonin 5HT1A receptors in the human brain.
Page 1229
Figure 4

123I-MIBG and 18F-FDG in neuroblastoma: Sharp and colleagues assess differences in diagnostic utility of 123I- MIBG scintigraphy and 18F-FDG PET in patients with stages 1–4 neuroblastoma.
Page 1237

Parkin gene mutations and dopamine: Ribeiro and colleagues use 18F-fluoro-L-DOPA, 11C-PE2I, and 11C-raclopride PET to characterize patterns of dopaminergic lesions and related clinical manifestations in young-onset Parkinson disease patients with and without mutations of the Parkin gene.
Page 1244

18F-Flutemetamol PET: Nelissen and colleagues report on a phase 1 study of 18F-flutemetamol, a thioflavin derivative of Pittsburgh compound B, including brain kinetic modeling, image acquisition optimization, and comparison of brain retention in Alzheimer disease patients and healthy controls.
Page 1251
Figure 5

Altered serotonin transporters in AD: Ouchi and colleagues examine the relationship of clinical depression in early-to-moderate Alzheimer disease to changes in the brain serotoninergic system and glucose metabolism as assessed by 11C-DASB and 18F-FDG PET.
Page 1260

P-gp activity at the human BBB: Muzi and colleagues expand on previous studies designed to use 11C-verapamil PET to image cyclosporine inhibition of multiple-drug resistance transporter P-glycoprotein activity at the blood–brain barrier in healthy humans.
Page 1267
Figure 6

Novel translocator protein tracer: Endres and colleagues describe initial PET studies in humans with 11C-DPA-713, a radioligand that binds to translocator proteins with high affinity, and discuss potential applications in assessment of neuroinflammation.
Page 1276

11C-Methionine PET in MI: Morooka and colleagues examine whether 11C-methionine localizes in areas of myocardial infarction after successful reperfusion and assess the potential for PET imaging of the initial processes of remodeling.
Page 1283

Single-shot cardiorenal scintigraphy: Fommei and colleagues explore the hypothesis that a single combined cardiorenal 99mTc-tetrofosmin scintigraphy study can allow simultaneous investigation of cardiac and renal pathology in cardiovascular patients.
Page 1288
Figure 7

Predictive CAD testing: Shaw and Narula provide an educational overview of risk assessment, predictive accuracy, and economic outcomes for 3 commonly applied cardiac imaging procedures and highlight the potential added value of hybrid imaging.
Page 1296

Measuring spatial resolution in PET: Lodge and colleagues report on a quality assurance method for measuring spatial resolution in PET, designed to assist in standardization of data collection for enhanced comparison of results, particularly those from multicenter trials.
Page 1307

TOF PET tumor detectability: Kadrmas and colleagues evaluate the effect of time-of-flight technology on observer performance in detecting and localizing focal warm lesions in noisy PET images acquired in an anthropomorphic phantom.
Page 1315

Kinetic model for CSF RIT delivery: Lv and colleagues describe a pharmacokinetic model to evaluate the role of kinetic and transport parameters of radioimmunotherapy designed to treat leptomeningeal metastases using antibodies administered directly into the cerebrospinal fluid.
Page 1324

MDR1 influences 64Cu-ATSM retention: Liu and colleagues investigate the role of multidrug resistance type 1 protein expression in accumulation and retention of two 64C-labeled tracers and discuss the implications for imaging of tumor hypoxia.
Page 1332

SPECT/CT and HER2 expression: McLarty and colleagues describe animal studies on 111In-DTPA-pertuzumab SPECT detection of early molecular response to trastuzumab as indicated by HER2 downregulation and of tumor response with decreased numbers of HER2-positive viable tumor cells.
Page 1340
Figure 8

Central nAChR tracer: Valette and colleagues report on in vitro characterization and in vivo primate studies of a novel radioligand for PET imaging of central nicotinic acetylcholine receptors.
Page 1349

Quantitative imaging of angiogenesis: Dobrucki and colleagues report on validation studies of a semiautomated approach for serial quantitative evaluation of peripheral angiogenesis with micro-SPECT/CT.
Page 1356
Figure 9

K-Ras and uptake in thyroid cancer: Prante and colleagues explore molecular mechanisms behind increases in 18F-FDG uptake on PET imaging in dedifferentiated thyroid cancer, with findings that point to oncogene activation of intracellular signal transduction cascades.
Page 1364

Apoptosis in right ventricular disease: Campian and colleagues study the role of apoptosis in this setting by monitoring disease progression and treatment response with 99mTc-annexin-V scintigraphy in rats.
Page 1371

Serum protein binding of 123I-IMP: Kuga and colleagues investigate whether amino acid infusion can improve cerebral accumulation of this SPECT tracer by competitive displacement of serum protein binding.
Page 1378
Figure 10

ON THE COVER

Time-of-flight PET significantly improves observer performance in detecting focal lesions on a noisy background, as illustrated by this 18F-FDG PET/CT scan of a patient with esophageal cancer and a body mass index of 27. The reconstructions that include time-of-flight information show improved uniformity in the liver and mediastinal region and better delineate the bone marrow in the ribs and spine.

See page 1322.
Figure 11


Related articles in JNM:

Strategies for Molecular Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase in Cancer
Eyal Mishani and Aviv Hagooly
JNM 2009 50: 1199-1202. [Abstract] [Full Text]  

The Importance of Kinetic Enhancement
Marc S. Berridge
JNM 2009 50: 1203-1204. [Full Text]  

Comparison of Whole-Body PET/CT, Dedicated High-Resolution Head and Neck PET/CT, and Contrast-Enhanced CT in Preoperative Staging of Clinically M0 Squamous Cell Carcinoma of the Head and Neck
Rosana S. Rodrigues, Fernando A. Bozza, Paul E. Christian, John M. Hoffman, Regan I. Butterfield, Carl R. Christensen, Marta Heilbrun, Richard H. Wiggins, III, Jason P. Hunt, Brandon G. Bentz, Ying J. Hitchcock, and Kathryn A. Morton
JNM 2009 50: 1205-1213. [Abstract] [Full Text]  

Bone Metastases in Patients with Neuroendocrine Tumor: 68Ga-DOTA-Tyr3-Octreotide PET in Comparison to CT and Bone Scintigraphy
Daniel Putzer, Michael Gabriel, Benjamin Henninger, Dorota Kendler, Christian Uprimny, Georg Dobrozemsky, Clemens Decristoforo, Reto Josef Bale, Werner Jaschke, and Irene Johanna Virgolini
JNM 2009 50: 1214-1221. [Abstract] [Full Text]  

The Importance of Acetyl Coenzyme A Synthetase for 11C-Acetate Uptake and Cell Survival in Hepatocellular Carcinoma
Mijin Yun, Seong-Hye Bang, Jae Woo Kim, Jun Young Park, Kyoung Sup Kim, and Jong Doo Lee
JNM 2009 50: 1222-1228. [Abstract] [Full Text]  

Parametric Mapping of 5HT1A Receptor Sites in the Human Brain with the Hypotime Method: Theory and Normal Values
Mette Møller, Anders Rodell, and Albert Gjedde
JNM 2009 50: 1229-1236. [Abstract] [Full Text]  

123I-MIBG Scintigraphy and 18F-FDG PET in Neuroblastoma
Susan E. Sharp, Barry L. Shulkin, Michael J. Gelfand, Shelia Salisbury, and Wayne L. Furman
JNM 2009 50: 1237-1243. [Abstract] [Full Text]  

A Multitracer Dopaminergic PET Study of Young-Onset Parkinsonian Patients With and Without Parkin Gene Mutations
Maria-João Ribeiro, Stéphane Thobois, Ebba Lohmann, Sophie Tezenas du Montcel, Suzanne Lesage, Antoine Pelissolo, Bruno Dubois, Luc Mallet, Pierre Pollak, Yves Agid, Emmanuel Broussolle, Alexis Brice, Philippe Remy, and and The French Parkinson's Disease Genetics Study Group
JNM 2009 50: 1244-1250. [Abstract] [Full Text]  

Phase 1 Study of the Pittsburgh Compound B Derivative 18F-Flutemetamol in Healthy Volunteers and Patients with Probable Alzheimer Disease
Natalie Nelissen, Koen Van Laere, Lennart Thurfjell, Rikard Owenius, Mathieu Vandenbulcke, Michel Koole, Guy Bormans, David J. Brooks, and Rik Vandenberghe
JNM 2009 50: 1251-1259. [Abstract] [Full Text]  

Altered Brain Serotonin Transporter and Associated Glucose Metabolism in Alzheimer Disease
Yasuomi Ouchi, Etsuji Yoshikawa, Masami Futatsubashi, Shunsuke Yagi, Takatoshi Ueki, and Kazuhiko Nakamura
JNM 2009 50: 1260-1266. [Abstract] [Full Text]  

Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans
Mark Muzi, David A. Mankoff, Jeanne M. Link, Steve Shoner, Ann C. Collier, Lucy Sasongko, and Jashvant D. Unadkat
JNM 2009 50: 1267-1275. [Abstract] [Full Text]  

Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans
Christopher J. Endres, Martin G. Pomper, Michelle James, Ovsev Uzuner, Dima A. Hammoud, Crystal C. Watkins, Aaron Reynolds, John Hilton, Robert F. Dannals, and Michael Kassiou
JNM 2009 50: 1276-1282. [Abstract] [Full Text]  

11C-Methionine PET of Acute Myocardial Infarction
Miyako Morooka, Kazuo Kubota, Hiromu Kadowaki, Kimiteru Ito, Osamu Okazaki, Mitsuo Kashida, Takuya Mitsumoto, Ren Iwata, Kuni Ohtomo, and Michiaki Hiroe
JNM 2009 50: 1283-1287. [Abstract] [Full Text]  

Single-Shot Cardiorenal Scintigraphy with 99mTc-Tetrofosmin: A Dynamic Characterization at Rest and During Adenosine Infusion
Enza Fommei, Laura Bruselli, Andrea Ripoli, Alessia Gimelli, Sergio Ghione, Assuero Giorgetti, Annette Kush, Irene D'Aragona Tagliavia, Claudio Passino, and Paolo Marzullo
JNM 2009 50: 1288-1295. [Abstract] [Full Text]  

Risk Assessment and Predictive Value of Coronary Artery Disease Testing
Leslee J. Shaw and Jagat Narula
JNM 2009 50: 1296-1306. [Abstract] [Full Text]  

A Practical, Automated Quality Assurance Method for Measuring Spatial Resolution in PET
Martin A. Lodge, Arman Rahmim, and Richard L. Wahl
JNM 2009 50: 1307-1314. [Abstract] [Full Text]  

Impact of Time-of-Flight on PET Tumor Detection
Dan J. Kadrmas, Michael E. Casey, Maurizio Conti, Bjoern W. Jakoby, Cristina Lois, and David W. Townsend
JNM 2009 50: 1315-1323. [Abstract] [Full Text]  

A Pharmacokinetic Model for Radioimmunotherapy Delivered Through Cerebrospinal Fluid for the Treatment of Leptomeningeal Metastases
Yonggang Lv, Nai-Kong V. Cheung, and Bingmei M. Fu
JNM 2009 50: 1324-1331. [Abstract] [Full Text]  

Retention of the Radiotracers 64Cu-ATSM and 64Cu-PTSM in Human and Murine Tumors Is Influenced by MDR1 Protein Expression
Jun Liu, Asghar Hajibeigi, Gang Ren, Mai Lin, Wasana Siyambalapitiyage, Zhisu Liu, Evan Simpson, Robert W. Parkey, Xiankai Sun, and Orhan K. Öz
JNM 2009 50: 1332-1339. [Abstract] [Full Text]  

Micro-SPECT/CT with 111In-DTPA-Pertuzumab Sensitively Detects Trastuzumab-Mediated HER2 Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts
Kristin McLarty, Bart Cornelissen, Zhongli Cai, Deborah A. Scollard, Danny L. Costantini, Susan J. Done, and Raymond M. Reilly
JNM 2009 50: 1340-1348. [Abstract] [Full Text]  

18F-ZW-104: A New Radioligand for Imaging Neuronal Nicotinic Acetylcholine Receptors—In Vitro Binding Properties and PET Studies in Baboons
Héric Valette, Yingxiang Xiao, Marie-Anne Peyronneau, Annelaure Damont, Alan P. Kozikowski, Zhi-Liang Wei, Michael Kassiou, Kenneth J. Kellar, Frédéric Dollé, and Michel Bottlaender
JNM 2009 50: 1349-1355. [Abstract] [Full Text]  

Serial Noninvasive Targeted Imaging of Peripheral Angiogenesis: Validation and Application of a Semiautomated Quantitative Approach
Lawrence W. Dobrucki, Donald P. Dione, Leszek Kalinowski, Donna Dione, Marivi Mendizabal, Jun Yu, Xenophon Papademetris, William C. Sessa, and Albert J. Sinusas
JNM 2009 50: 1356-1363. [Abstract] [Full Text]  

Regulation of Uptake of 18F-FDG by a Follicular Human Thyroid Cancer Cell Line with Mutation-Activated K-Ras
Olaf Prante, Simone Maschauer, Valerie Fremont, Julia Reinfelder, Robert Stoehr, Mariusz Szkudlinski, Bruce Weintraub, Arndt Hartmann, and Torsten Kuwert
JNM 2009 50: 1364-1370. [Abstract] [Full Text]  

Serial Noninvasive Assessment of Apoptosis During Right Ventricular Disease Progression in Rats
Maria E. Campian, Hein J. Verberne, Maxim Hardziyenka, Kora de Bruin, Mariana Selwaness, Maurice J.B. van den Hoff, Jan M. Ruijter, Berthe L.F. van Eck-Smit, Jacques M.T. de Bakker, and Hanno L. Tan
JNM 2009 50: 1371-1377. [Abstract] [Full Text]  

Competitive Displacement of Serum Protein Binding of Radiopharmaceuticals with Amino Acid Infusion Investigated with N-Isopropyl-p-123I-Iodoamphetamine
Noriyuki Kuga, Naoto Shikano, Norito Takamura, Ryuichi Nishii, Keishi Yamasaki, Masato Kobayashi, Shigeki Nagamachi, Shozo Tamura, and Keiichi Kawai
JNM 2009 50: 1378-1383. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE