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FIGURE 1. Timeline of signal and detector advances in the history of nuclear cardiac stress testing and accuracy of current techniques. (A) Time points of initial recognition that ECG and radiotracers provide diagnostic information for myocardial perfusion and metabolism. (B) Time span of use of detection modalities in cardiac stress testing. (C) Diagnostic information provided by stress testing as change from pretest to posttest likelihood of angiographically confirmed CAD. Bayesian curves are derived from current levels of sensitivity (Sens) and specificity (Spec) for each protocol: ECG-Exercise (16), SPECT (17), and PET (18).
