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Journal of Nuclear Medicine Vol. 49 No. 12 11A-12A
© 2008 by Society of Nuclear Medicine

This Month in JNM

Focus on molecular imaging: Gilad and colleagues provide an introduction to MRI reporter genes, which have the unique advantage of offering gene expression information that can be coregistered with anatomic and functional data.
Page 1905
Figure 1

Exploring resolved chest pain: Dilsizian looks at current evidence about and imaging approaches to metabolic change after transient episodes of myocardial ischemia and previews a related article in this issue of JNM.
Page 1909

Dual-tracer PET/CT in HCC: Park and colleagues evaluate the addition of 11C-acetate to 18F-FDG PET/CT in the detection of primary and metastatic hepatocellular carcinoma.
Page 1912
Figure 2

Identifying elevated OEF: Hokari and colleagues report on a methodology designed to improve the validity of acetazolamide testing for elevated oxygen extraction fraction in assessment for subsequent ischemic stroke.
Page 1922

PET in specific cancers: Hillner and colleagues expand on their previous report of aggregate data from the National Oncologic PET Registry by detailing results for specific cancer types and indications for testing.
Page 1928

PET and recurrent cervical cancer: van der Veldt and colleagues investigate the clinical value of 18F-FDG PET in clarification of diagnosis and enhancement of management in suspected recurrence of cervical cancer.
Page 1936

Novel PET hypoxia tracer: Komar and colleagues explore the utility of 18F-EF5, one of a new group of etanidazole-based compounds, in PET/CT imaging of hypoxia in patients with squamous cell carcinoma of the head and neck.
Page 1944
Figure 3

131I SPECT/CT in thyroid cancer: Chen and colleagues compare the relative merits of 131I SPECT/CT and whole-body scintigraphy in the management of patients with differentiated thyroid carcinoma.
Page 1952
Figure 4

CAD in bone scans: Sadik and colleagues describe the development of an automated system for computer-assisted interpretation of whole-body bone scans performed to determine the presence or absence of metastases.
Page 1958
Figure 5

MAP kinase and NIS function: Jung and colleagues investigate the role of mitogen-activated protein kinase–linked signaling on the regulation of sodium/iodide symporter function in cancer cells and discuss the resulting implications for radioiodide therapy.
Page 1966
Figure 6

Heterogeneity in sarcoma: Eary and colleagues report on a study designed to determine whether heterogeneity in 18F-FDG spatial distribution on PET can be used to predict tumor biologic aggressiveness and patient outcomes.
Page 1973
Figure 7

PET/CT in FUO: Keidar and colleagues evaluate the role of 18F-FDG in the investigation of fever of unknown origin and review the potential of this technique for initial noninvasive clinical assessment.
Page 1980
Figure 8

Persistent uptake after exercise: Dou and colleagues explore whether increased regional myocardial 18F-FDG uptake in patients with coronary artery disease persists in rest imaging 24 h after an episode of exercise-induced myocardial ischemia.
Page 1986

Attenuation correction of 82Rb PET/CT: Slomka and colleagues compare transmission CT–based and CT-based attenuation for myocardial perfusion PET/CT images.
Page 1992
Figure 9

Brain metabolism in HIV and drug use: Georgiou and colleagues use 18F-FDG PET to investigate both the separate and coexisting effects of HIV-1 infection and injected drug use on brain metabolic processes.
Page 1999
Figure 10

Neural substrates of Parkinson's dementia: Lee and colleagues investigate changes in cerebral glucose metabolism after cholinesterase inhibitor therapy in patients with Parkinson's disease dementia to determine whether cognitive improvements are reflected in changes of cerebral metabolic patterns.
Page 2006
Figure 11

SPECT/CT in primary hyperparathyroidism: Neumann and colleagues compare the diagnostic accuracy of 99mTc-sestamibi/123I subtraction SPECT with SPECT/CT for preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism.
Page 2012
Figure 12

Kinetic modeling of 11C-HOMADAM: Nye and colleagues report on a reliable model describing healthy human brain uptake kinetics for this novel PET radioligand with high affinity and selectivity for the serotonin transporter.
Page 2018
Figure 13

Radioimmunotherapy for Graves disease: Eterovic and colleagues evaluate the effects of self-absorption of 131I radiation in the follicular colloid on the absorbed dose to thyroid follicular cells.
Page 2026

Novel prostate cancer tracers: Apolo and colleagues provide an educational overview of current molecular imaging modalities that have been clinically tested in metastatic prostate cancer, including consideration of conformity with current prostate cancer clinical trial designs.
Page 2031

mGluR5 receptors in human brain: Brown and colleagues explore the characteristics and potential of 18F-SP203, a novel PET radioligand for metabotropic glutamate subtype 5 receptors, in healthy human brains.
Page 2042
Figure 14

Cytotoxicity of {sigma}-ligands: Rybczynska and colleagues quantify receptor occupancies associated with the cytotoxic effect of {sigma}-ligands and assess dose-dependent changes of cellular metabolism in a tumor cell line.
Page 2049

18F-FLT kinetics in mice: Kim and colleagues describe a kinetic modeling analysis method for quantitative 18F-FLT PET proliferation imaging in subcutaneous tumor models in mice.
Page 2057

ON THE COVER

Regional myocardial 18F-FDG uptake is highly specific and sensitive for exercise-induced myocardial ischemia and may persist for 24 h after an episode. Exercise and rest 99mTc-sestamibi perfusion and 18F-FDG imaging were performed on this patient with exertional angina. Exercise-induced perfusion abnormality was reversible on rest images, and intense 18F-FDG uptake on exercise images was not seen on rest images. The patient had 85% right coronary artery stenosis.
Figure 15

See page 1989.


Related articles in JNM:

MRI Reporter Genes
Assaf A. Gilad, Keren Ziv, Michael T. McMahon, Peter C.M. van Zijl, Michal Neeman, and Jeff W.M. Bulte
JNM 2008 49: 1905-1908. [Abstract] [Full Text]  

18F-FDG Uptake as a Surrogate Marker for Antecedent Ischemia
Vasken Dilsizian
JNM 2008 49: 1909-1911. [Full Text]  

A Prospective Evaluation of 18F-FDG and 11C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma
Joong-Won Park, Ji Hoon Kim, Seok Ki Kim, Keon Wook Kang, Kyung Woo Park, Jun-Il Choi, Woo Jin Lee, Chang-Min Kim, and Byung Ho Nam
JNM 2008 49: 1912-1921. [Abstract] [Full Text]  

Combination of a Mean Transit Time Measurement with an Acetazolamide Test Increases Predictive Power to Identify Elevated Oxygen Extraction Fraction in Occlusive Carotid Artery Diseases
Masaaki Hokari, Satoshi Kuroda, Tohru Shiga, Naoki Nakayama, Nagara Tamaki, and Yoshinobu Iwasaki
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Bruce E. Hillner, Barry A. Siegel, Anthony F. Shields, Dawei Liu, Ilana F. Gareen, Ed Hunt, and R. Edward Coleman
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Clarifying the Diagnosis of Clinically Suspected Recurrence of Cervical Cancer: Impact of 18F-FDG PET
Astrid A.M. van der Veldt, Marrije R. Buist, Marchien W. van Baal, Emile F. Comans, Otto S. Hoekstra, and Carla F.M. Molthoff
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18F-EF5: A New PET Tracer for Imaging Hypoxia in Head and Neck Cancer
Gaber Komar, Marko Seppänen, Olli Eskola, Paula Lindholm, Tove J. Grönroos, Sarita Forsback, Hannu Sipilä, Sydney M. Evans, Olof Solin, and Heikki Minn
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Incremental Value of 131I SPECT/CT in the Management of Patients with Differentiated Thyroid Carcinoma
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Computer-Assisted Interpretation of Planar Whole-Body Bone Scans
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JNM 2008 49: 1958-1965. [Abstract] [Full Text]  

Mitogen-Activated Protein Kinase Signaling Enhances Sodium Iodide Symporter Function and Efficacy of Radioiodide Therapy in Nonthyroidal Cancer Cells
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Fever of Unknown Origin: The Role of 18F-FDG PET/CT
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JNM 2008 49: 1980-1985. [Abstract] [Full Text]  

Myocardial 18F-FDG Uptake After Exercise-Induced Myocardial Ischemia in Patients with Coronary Artery Disease
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JNM 2008 49: 1986-1991. [Abstract] [Full Text]  

Comparison of Myocardial Perfusion 82Rb PET Performed with CT- and Transmission CT–Based Attenuation Correction
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Analysis of the Effects of Injecting Drug Use and HIV-1 Infection on 18F-FDG PET Brain Metabolism
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Preoperative 123I/99mTc-Sestamibi Subtraction SPECT and SPECT/CT in Primary Hyperparathyroidism
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Compartmental Modeling of 11C-HOMADAM Binding to the Serotonin Transporter in the Healthy Human Brain
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Planning of 131I Therapy for Graves Disease Based on the Radiation Dose to Thyroid Follicular Cells
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JNM 2008 49: 2031-2041. [Abstract] [Full Text]  

Metabotropic Glutamate Subtype 5 Receptors Are Quantified in the Human Brain with a Novel Radioligand for PET
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