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FIGURE 7. Sequential PET studies of tumors growing in FVB/N female mice. NG4TL4/tet-off-mNLSHSV1-TK:dMODC cells (dTK), G4TL4/tet-off-mNLSHSV1-TK cells (mNLSTK), NG4TL4/tet-off-HSV1-TK cells (TK), or NG4TL4 control cells (wild-type [WT]) were injected subcutaneously into 3 separate sites in single mice. When tumors reached at least 5 mm, mouse was imaged with 18F-FHBG on sequential days. Doxycycline (500 µg/mL) was administered intraperitoneally and also added to cage water supply for 1 d. Mouse was scanned with 18F-FHBG again 24 h after exposure to doxycycline.
