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FIGURE 6. Dynamic gene expression of HSV1-TK, mNLSHSV1-TK, or mNLSHSV1-TK:dMODC mediated by series of doxycycline inductions. HSV1-TK, mNLSHSV1-TK, and mNLSHSV1-TK:dMODC gene expression of NG4TL4/tet-off-HSV1-TK cells, NG4TL4/tet-off-mNLSHSV1-TK, and NG4TL4/tet-off-mNLSHSV1-TK:dMODC cell lines mediated by series of doxycycline inductions were monitored using in vitro assay for HSV1-TK enzyme activity. Open and closed arrows indicate changes in medium with or without doxycycline, respectively. Data points represent mean ± SD of 3 independent experiments.
