JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
Journal of Nuclear Medicine Vol. 49 No. 1 11A-12A
© 2008 by Society of Nuclear Medicine

This Month in JNM

Optical molecular imaging: Luker and Luker provide an overview of current optical imaging technologies for preclinical and clinical applications and highlight the potential of these techniques in advancing molecular medicine.
Page 1
Figure 1

V/Q scans remain valuable: Freeman compares the advantages of traditional ventilation-perfusion scintigraphy and the rapidly increasing use of multidetector CT angiography in the detection of pulmonary embolic disease, with special reference to radiation exposure.
Page 5

Weighing posttherapy PET benefits: Juweid reviews supporting evidence and recent international recommendations for routine use of 18F-FDG PET for posttreatment assessment of patients with Hodgkin's disease and diffuse large B-cell lymphoma.
Page 9

PET and lymphoma response: Terasawa and colleagues report on a systematic metaanalysis of the utility of 18F-FDG in detecting residual disease after first-line therapy for Hodgkin's disease and aggressive non-Hodgkin's lymphoma.
Page 13

Complementary PET tracers: Beer and colleagues describe investigations to determine the extent and nature of correlation between 18F-galacto-RGD and 18F-FDG PET assessments of {alpha}vβ3 expression and glucose metabolism, respectively, in cancer patients.
Page 22
Figure 2

{alpha}-Particle radioimmunotherapy: Zalutsky and colleagues explore the feasibility of regionally targeted, postresection radiotherapy with a 211At-labeled monoclonal antibody in patients with recurrent malignant brain tumors.
Page 30
Figure 3

Probabilistic MCA atlas: Kim and colleagues describe a population-based technique for the use of SPECT in generating probabilistic maps of blood flow distribution in the middle cerebral artery.
Page 39

Mapping cortical glucose consumption: Klein and colleagues investigate the applicability of cortical flattening of MR images coregistered to high-resolution research tomographic 18F-FDG PET.
Page 44
Figure 4

Resolving 3D 15O brain PET: Ibaraki and colleagues compare 3D quantitative 15O PET with 2D PET in assessment of brain pathophysiology and discuss optimal means for scatter correction.
Page 50

PET and cochlear implants: Coez and colleagues analyze cochlear implant activation of human temporal voice areas using a standardized H215O PET paradigm adapted from previous functional MR imaging studies.
Page 60
Figure 5

18F-fluoride bone scans: Grant and colleagues provide an educational overview of 18F-fluoride PET in skeletal imaging, including production, pharmacology, dosimetry, clinical applications in both benign and malignant disease, and practical and technical issues.
Page 68
Figure 6

High-resolution PET insert: Wu and colleagues detail the development of a prototype system to evaluate an insert device designed to achieve higher resolution with an existing general-purpose animal PET scanner.
Page 79

Small-animal SPECT/MRI: Goetz and colleagues report on the development of a pinhole SPECT/low-field MRI hybrid system with potential as a low-cost solution for anatomic and functional preclinical molecular imaging.
Page 88

In vivo islet cell SPECT: Tai and colleagues visualize both reporter gene expression in and location of transplanted pancreatic cells in living mice using dual-isotope SPECT, a technique with promise in monitoring innovative treatments for diabetes.
Page 94

64Cu-Nanoparticle lung imaging: Rossin and colleagues evaluate the use of PET to image lung uptake and distribution of radiolabeled and antibody-coated fluorescent nanoparticles and discuss the potential for this approach in preclinical screening of novel drug delivery agents.
Page 103
Figure 7

Receptor imaging in prostate cancer: Zhang and colleagues describe the development of a probe specific for a 64Cu-labeled VPAC1 receptor and initial PET imaging of experimental and spontaneous human prostate cancers in mice.
Page 112
Figure 8

99mTc-GSA imaging in liver regeneration: de Graaf and colleagues report on 99mTc-DTPA-galactosyl serum albumin scintigraphy combined with SPECT for the assessment of liver function and liver functional volume in normal and regenerating rat livers.
Page 122

microPET imaging of c-Met antibody: Tseng and colleagues use small animal 18F-FDG PET to investigate the efficacy of a novel antineoplastic chemotherapeutic agent and discuss the potential of this approach in assessing early response to therapy.
Page 129

11C-Methionine PET in tumor differentiation: Zhao and colleagues detail the respective potentials of 18F-FLT and 11C-methionine PET in differentiating malignant tumors from granulomas and compare these capabilities with those of 18F-FDG PET.
Page 135

Destabilized HSV1-TK reporter systems: Hsieh and colleagues describe the creation of a transcription reporter and molecular probe that allow for dynamic studies of short-time-scale gene expression events.
Page 142
Figure 9

Electron dose distribution: Champion and colleagues introduce a Monte Carlo code for assessing electron dose for isolated 131I in spheres of various sizes, provide representative S values, and discuss the potential for evaluating electron map deposits for any isotope.Page 151
Figure 10

Pretargeting with bispecific antibodies: Goldenberg and colleagues report on the "Dock-and-Lock" method, a new approach to developing bioactive targeting molecules with multivalency and multifunctionality for improved cancer imaging and therapy.
Page 158
Figure 11


ON THE COVER

In small-animal SPECT, regions of increased radiotracer uptake are more easily localized through coregistration with anatomic images of the same animal. Here, low-field-strength MR images of the 3 orthogonal planes are coregistered with pinhole 99mTc-DMSA SPECT images. The matching of the kidneys between the functional and the anatomic images demonstrates the practical advantage of this dual-modality system.
Figure 12

See page 91.

 


Related articles in JNM:

Optical Imaging: Current Applications and Future Directions
Gary D. Luker and Kathryn E. Luker
JNM 2008 49: 1-4. [Abstract] [Full Text]  

In Vivo Imaging of 64Cu-Labeled Polymer Nanoparticles Targeted to the Lung Endothelium
Raffaella Rossin, Silvia Muro, Michael J. Welch, Vladimir R. Muzykantov, and Daniel P. Schuster
JNM 2008 49: 103-111. [Abstract] [Full Text]  

PET Imaging of VPAC1 Expression in Experimental and Spontaneous Prostate Cancer
Kaijun Zhang, Mohan R. Aruva, Nylla Shanthly, Christopher A. Cardi, Satish Rattan, Chirag Patel, Christopher Kim, Peter A. McCue, Eric Wickstrom, and Mathew L. Thakur
JNM 2008 49: 112-121. [Abstract] [Full Text]  

99mTc-GSA Scintigraphy with SPECT for Assessment of Hepatic Function and Functional Volume During Liver Regeneration in a Rat Model of Partial Hepatectomy
Wilmar de Graaf, Reeta L. Veteläinen, Kora de Bruin, Arlène K. van Vliet, Thomas M. van Gulik, and Roelof J. Bennink
JNM 2008 49: 122-128. [Abstract] [Full Text]  

Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by 18F-FDG Small-Animal PET
Jeffrey R. Tseng, Keon Wook Kang, Mangal Dandekar, Shahriar Yaghoubi, Joseph H. Lee, James G. Christensen, Stephen Muir, Patrick W. Vincent, Neil R. Michaud, and Sanjiv S. Gambhir
JNM 2008 49: 129-134. [Abstract] [Full Text]  

18F-FDG PET for Posttherapy Assessment of Hodgkin's Disease and Aggressive Non-Hodgkin's Lymphoma: A Systematic Review
Teruhiko Terasawa, Takashi Nihashi, Tomomitsu Hotta, and Hirokazu Nagai
JNM 2008 49: 13-21. [Abstract] [Full Text]  

Usefulness of 11C-Methionine for Differentiating Tumors from Granulomas in Experimental Rat Models: A Comparison with 18F-FDG and 18F-FLT
Songji Zhao, Yuji Kuge, Masashi Kohanawa, Toshiyuki Takahashi, Yan Zhao, Min Yi, Kakuko Kanegae, Koh-ichi Seki, and Nagara Tamaki
JNM 2008 49: 135-141. [Abstract] [Full Text]  

Generation of Destabilized Herpes Simplex Virus Type 1 Thymidine Kinase as Transcription Reporter for PET Reporter Systems in Molecular–Genetic Imaging
Chia-Hung Hsieh, Fu-Du Chen, Hsin-Ell Wang, Jeng-Jong Hwang, Chi-Wei Chang, Yi-Jang Lee, Juri G. Gelovani, and Ren-Shyan Liu
JNM 2008 49: 142-150. [Abstract] [Full Text]  

CELLDOSE: A Monte Carlo Code to Assess Electron Dose Distribution—S Values for 131I in Spheres of Various Sizes
Christophe Champion, Paolo Zanotti-Fregonara, and Elif Hindié
JNM 2008 49: 151-157. [Abstract] [Full Text]  

Multifunctional Antibodies by the Dock-and-Lock Method for Improved Cancer Imaging and Therapy by Pretargeting
David M. Goldenberg, Edmund A. Rossi, Robert M. Sharkey, William J. McBride, and Chien-Hsing Chang
JNM 2008 49: 158-163. [Abstract] [Full Text]  

Comparison of Integrin {alpha}vβ3 Expression and Glucose Metabolism in Primary and Metastatic Lesions in Cancer Patients: A PET Study Using 18F-Galacto-RGD and 18F-FDG
Ambros J. Beer, Sylvie Lorenzen, Stephan Metz, Ken Herrmann, Petra Watzlowik, Hans-Jürgen Wester, Christian Peschel, Florian Lordick, and Markus Schwaiger
JNM 2008 49: 22-29. [Abstract] [Full Text]  

Clinical Experience with {alpha}-Particle–Emitting 211At: Treatment of Recurrent Brain Tumor Patients with 211At-Labeled Chimeric Antitenascin Monoclonal Antibody 81C6
Michael R. Zalutsky, David A. Reardon, Gamal Akabani, R. Edward Coleman, Allan H. Friedman, Henry S. Friedman, Roger E. McLendon, Terence Z. Wong, and Darell D. Bigner
JNM 2008 49: 30-38. [Abstract] [Full Text]  

Probabilistic Anatomic Mapping of Cerebral Blood Flow Distribution of the Middle Cerebral Artery
Seong-Jang Kim, In-Ju Kim, Yong-Ki Kim, Tae-Hong Lee, Jung Sub Lee, Sungmin Jun, Hyun-Yeol Nam, Jae Sung Lee, Yu Kyeong Kim, and Dong Soo Lee
JNM 2008 49: 39-43. [Abstract] [Full Text]  

Cortical Flattening Applied to High-Resolution 18F-FDG PET
Johannes C. Klein, Karl Herholz, Klaus Wienhard, and Wolf-Dieter Heiss
JNM 2008 49: 44-49. [Abstract] [Full Text]  

Don't Bury the V/Q Scan: It's as Good as Multidetector CT Angiograms with a Lot Less Radiation Exposure
Leonard M. Freeman
JNM 2008 49: 5-8. [Full Text]  

Quantification of Cerebral Blood Flow and Oxygen Metabolism with 3-Dimensional PET and 15O: Validation by Comparison with 2-Dimensional PET
Masanobu Ibaraki, Shuichi Miura, Eku Shimosegawa, Shigeki Sugawara, Tetsuro Mizuta, Akihiro Ishikawa, and Masaharu Amano
JNM 2008 49: 50-59. [Abstract] [Full Text]  

Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations
Arnaud Coez, Monica Zilbovicius, Evelyne Ferrary, Didier Bouccara, Isabelle Mosnier, Emmanuèle Ambert-Dahan, Eric Bizaguet, André Syrota, Yves Samson, and Olivier Sterkers
JNM 2008 49: 60-67. [Abstract] [Full Text]  

Skeletal PET with 18F-Fluoride: Applying New Technology to an Old Tracer
Frederick D. Grant, Frederic H. Fahey, Alan B. Packard, Royal T. Davis, Abass Alavi, and S. Ted Treves
JNM 2008 49: 68-78. [Abstract] [Full Text]  

A Feasibility Study of a Prototype PET Insert Device to Convert a General-Purpose Animal PET Scanner to Higher Resolution
Heyu Wu, Debashish Pal, Joseph A. O'Sullivan, and Yuan-Chuan Tai
JNM 2008 49: 79-87. [Abstract] [Full Text]  

SPECT Low-Field MRI System for Small-Animal Imaging
Christian Goetz, Elodie Breton, Philippe Choquet, Vincent Israel-Jost, and André Constantinesco
JNM 2008 49: 88-93. [Abstract] [Full Text]  

18F-FDG PET as a Routine Test for Posttherapy Assessment of Hodgkin's Disease and Aggressive Non-Hodgkin's Lymphoma: Where Is the Evidence?
Malik E. Juweid
JNM 2008 49: 9-12. [Full Text]  

Imaging of Gene Expression in Live Pancreatic Islet Cell Lines Using Dual-Isotope SPECT
Joo Ho Tai, Binh Nguyen, R. Glenn Wells, Michael S. Kovacs, Rebecca McGirr, Frank S. Prato, Timothy G. Morgan, and Savita Dhanvantari
JNM 2008 49: 94-102. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE