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FIGURE 3. Representative 18F-FDG PET coronal slices in a patient with left pleural mesothelioma (A) before chemotherapy and (B) after 1 cycle of chemotherapy, demonstrating reduction in the extent and intensity of 18F-FDG activity. The region generated by the semiautomated region-growing algorithm is shown on the coronal slice (C) before chemotherapy and (D) after chemotherapy. (A–D) illustrate one representative coronal slice both before and after chemotherapy; however, in practice the region is grown in 3 dimensions to define an overall volume of interest (VOI). (E) Histogram of the SUV voxel values of the VOI generated by the region-growing algorithm in this patient before chemotherapy (red line) and after chemotherapy (green line). The histogram demonstrates both a reduction in the numerical SUV values and in the overall volume of metabolically active tumor. The TGV fell to 30% of the prechemotherapy value.
