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FIGURE 2. Representative CT transaxial slices of a patient with mesothelioma (A) before chemotherapy and (B) after chemotherapy. Measurements according to modified RECIST criteria have been applied. The patient had a radiological partial response after 1 cycle of chemotherapy. The challenge of defining a measurement site to determine response is demonstrated. Representative 18F-FDG PET transverse, sagittal, and coronal slices in the same patient (C) before chemotherapy and (D) after 1 cycle of chemotherapy. A significant reduction in intensity and extent of 18F-FDG uptake in the left pleural cavity is demonstrated. The response is more clearly visualized on the 18F-FDG PET imaging, and the degree of change compared with baseline in the patient was greater (TGV fell to 11% of baseline on the postchemotherapy scan, compared with a fall to 63% of baseline on CT measurements).
